Model-Based Quantification of Blood Flow Rate and Oxygen Consumption Rate of Biological Tissues Using Image-Guided Near Infrared Light SpectroscopyZhen Yuan*
Faculty of Health Sciences, University of Macau, Av. Padre Tomás Pereira, Taipa, Macau, China
- *Corresponding Author:
- Zhen Yuan
Assistant Professor of Health Sciences
University of Macau
Av. Padre Tomás Pereira
Taipa, Macau, China
E-mail: [email protected]
Received Date: March 19, 2013; Accepted Date: April 21, 2013; Published Date: April 23, 2013
Citation:Yuan Z (2013) Model-Based Quantification of Blood Flow Rate and Oxygen Consumption Rate of Biological Tissues Using Image-Guided Near Infrared Light Spectroscopy. J Biosens Bioelectron 4:135. doi: 10.4172/2155-6210.1000135
Copyright: © 2013 Yuan Z. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Image-guided near infrared spectroscopy has been implemented to deduce the map of oxygen consumption rate and blood flow rate of biological tissues using a model-based method combined the noninvasive diffuse light measurement techniques. The developed method relies on optical imaging to recover the concentrations of oxygen and de-oxygen hemoglobin concentration of tissues, and the ordinary differential equations to recover the vascular parameters including oxygen consumption rate and blood flow rate. In particular, the mathematical model has been validated by both simulation and experimental tests.