alexa Modern Treatment of Rheumatoid Arthritis in Cows
ISSN: 2157-7579

Journal of Veterinary Science & Technology
Open Access

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Research Article

Modern Treatment of Rheumatoid Arthritis in Cows

Kalil MA*

Faculty of Medicine, Cairo University, Egypt

*Corresponding Author:
Kalil MA
Faculty of Medicine, Cairo University, Egypt
Tel/Fax: (202)23682030
E-mail: [email protected]

Received date: July 31, 2014; Accepted date: November 26, 2014; Published date: November 28, 2014

Citation: Kalil MA (2014) Modern Treatment of Rheumatoid Arthritis in Cows. J Veterinar Sci Technol 5:202. doi:10.4172/2157-7579.1000202

Copyright: © 2014 Kalil MA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease, which is thought to be one of the major public health problems in the world. The pathogenesis of rheumatoid arthritis is the topic of contemporary research. For most satisfactory outcome rheumatoid arthritis should be treated in early stage. Nevertheless, in spite of new progresses in rheumatoid arthritis medical therapy, their treatment still denotes an unmet medical requirement because of safety and efficacy anxieties through presently prescribed medications. The Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Glucocorticoids (GC) are employed respectively for the symptomatic and local therapy of rheumatoid arthritis. However the Tumor Necrosis Factor-α (TNF-α), Interleukin-1 (IL-1) and B cells have received increased interest resulting in numerous novel therapeutics. B-cell depletion agent (rituximab), Tumor Necrosis Factor-α inhibitors (etanercept, infliximab, and adalimumab), Interleukin-6 receptor blocker (tocilizumab), and T-cell co-stimulatory blocker (abatacept) are current biologics which are used as Disease-Modifying Antirheumatic Drugs (DMARDs) for the basic treatment of rheumatoid arthritis. Future treatments are consist of biosimilars, alternative Tumor Necrosis Factor-α inhibitors (golimumab and certolizumab), and kinase inhibitors (tofacitinib and fostamatinib).

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