Patients suffering from cardiovascular disease are vulnerable to physical and emotional stress. If, in addition, the patients have to undergo dental treatment, it will add to their stress. Cardiac patients may collapse in the dental clinic due to various cardiac emergencies or drug interactions. Hence, patients with cardiac disease may pose a significant risk in dental clinics. Multidisciplinary approach while treating medically compromised dental patients is mandatory to reduce complications and to achieve satisfactory results. This article gives an overview of inter-relationship of cardiac and dental pathogenesis and also aims to make recommendations that need to be followed in dental clinics while treating patients with associated cardiac problems.