Modified Fixed Two Step Short Protocol versus Classic Short Protocol in ICSI
|Mostafa Abdulla Elsayed*|
|Faculty of Medicine, Department of Obstetrics and Gyencology, IVF Division, Benha, Cairo, Egypt|
|Corresponding Author :||Dr Mostafa Abdulla Elsayed
Lecturer in Obstetrics and Gyencology Department
IVF Division, Benha, Faculty of Medicine, Cairo, Egypt
E-mail: [email protected]
|Received June 11, 2013; Accepted July 15, 2013; Published July 17, 2013|
|Citation: Elsayed MA (2013) Modified Fixed Two Step Short Protocol versus Classic Short Protocol in ICSI. J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol 1:105. doi: 10.4172/2375-4508.1000105|
|Copyright: © 2013 Elsayed MA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Objectives: The objective is to compare the new short protocol with traditional short protocol in ICSI programs.
Study design: Controlled trial.
Materials and methods: 40 cases scheduled for ICSI after a variable period of infertility classified into two
groups according to stimulation protocol. group1(20 case) with fixed 2 dose regimen (given merional ampoules) 4 ampoules first four days of stimulation the 3 ampoules thereafter while the other 20 patients given the traditional short protocol starting with 3 ampoules then dose adjusted according to patient response.
Results: Days of stimulation, Number of merional ampoules, were significantly less in the new modified short protocol than in the classic short protocol; while number of M2 oocytes, number of good embryos, pregnancy rate were significantly high in the group 1. Pregnancy rate was 75% in the new modified protocol and 50% with the classic short protocol.
Conclusion: The new short fixed 2 dose short protocol regimen offers a benefit in all the ways in ICSI success and pregnancy rate with less time of gonadotropin stimulation and less cost.