alexa Modifying Others Originality without Quote is an Act of Piracy
ISSN: 2161-0436

Human Genetics & Embryology
Open Access

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Letter to Editor

Modifying Others Originality without Quote is an Act of Piracy

Hsien-Hsiung Lee*

School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taiwan, Republic of China

*Corresponding Author:
Hsien-Hsiung Lee
School of Chinese Medicine
College of Chinese Medicine, China Medical University
91 Hsueh-Shih Road, Taichung 404, Taiwan
Tel: 886 3 9389073
E-mail: [email protected]; [email protected]

Received: May 05, 2015; Accepted: August 13, 2015; Published: August 15, 2015

Citation: Lee HH (2015) Modifying Other’s Originality without Quote is an Act of Piracy. Human Genet Embryol 5:128. doi:10.4172/2161-0436.1000128

Copyright:© 2015 Lee HH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A defective CYP21A2 gene downstream of the TNXB gene in congenital adrenal hyperplasia (CAH) falls into three categories: (a) small-scale conversions of CYP21A1P, (b) spontaneous mutations, and (c) chimeric RCCX modules that include the chimeric CYP21A1P/ CYP21A2 and TNXA/TNXB genes [1]. Most of the CYP21A2 mutations identified so far were a result of small-scale conversions of the CYP21A1P (up to 11 for CYP21A1P) during both meiosis and mitosis [2], which account for about 70%-80% of all CAH cases. The Chimeric CYP21A1P/CYP21A2 and TNXA/TNXB genes, which result from unequal cross-over (or deletions) during meiosis [2] and occur in ~20% of CAH alleles in most populations [1,3] respectively reflect the deletion of the 1/XCYP21A1P - XA - RP2 - C4B - 1/XCYP21A2 gene array (1/X indicates an uncertain fraction of the gene sequence) [1] and a deletion of the RP2 - C4B - CYP21A2 - 1/XTXNB gene array [1]. Their deletion range is about a 26- or 32-kb gene sequence which depends on whether C4B is the long or short gene (more commonly shown in the literature as being 30 kb). In fact, these different types of large-gene deletions in the RCCX region are generally considered to represent one event in many studies.

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