alexa Modifying Others Originality without Quote is an Act of Piracy
ISSN: 2161-0436

Human Genetics & Embryology
Open Access

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Letter to Editor

Modifying Others Originality without Quote is an Act of Piracy

Hsien-Hsiung Lee*

School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taiwan, Republic of China

*Corresponding Author:
Hsien-Hsiung Lee
School of Chinese Medicine
College of Chinese Medicine, China Medical University
91 Hsueh-Shih Road, Taichung 404, Taiwan
Tel: 886 3 9389073
E-mail: [email protected]; [email protected]

Received: May 05, 2015; Accepted: August 13, 2015; Published: August 15, 2015

Citation: Lee HH (2015) Modifying Other’s Originality without Quote is an Act of Piracy. Human Genet Embryol 5:128. doi:10.4172/2161-0436.1000128

Copyright:© 2015 Lee HH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



A defective CYP21A2 gene downstream of the TNXB gene in congenital adrenal hyperplasia (CAH) falls into three categories: (a) small-scale conversions of CYP21A1P, (b) spontaneous mutations, and (c) chimeric RCCX modules that include the chimeric CYP21A1P/ CYP21A2 and TNXA/TNXB genes [1]. Most of the CYP21A2 mutations identified so far were a result of small-scale conversions of the CYP21A1P (up to 11 for CYP21A1P) during both meiosis and mitosis [2], which account for about 70%-80% of all CAH cases. The Chimeric CYP21A1P/CYP21A2 and TNXA/TNXB genes, which result from unequal cross-over (or deletions) during meiosis [2] and occur in ~20% of CAH alleles in most populations [1,3] respectively reflect the deletion of the 1/XCYP21A1P - XA - RP2 - C4B - 1/XCYP21A2 gene array (1/X indicates an uncertain fraction of the gene sequence) [1] and a deletion of the RP2 - C4B - CYP21A2 - 1/XTXNB gene array [1]. Their deletion range is about a 26- or 32-kb gene sequence which depends on whether C4B is the long or short gene (more commonly shown in the literature as being 30 kb). In fact, these different types of large-gene deletions in the RCCX region are generally considered to represent one event in many studies.


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