Modularization Analysis of Brain Functional Network Using Fuzzy C-means Algorithm and Correlation in Resting StateZhuqing J1,2, Huan W1 and Ling Z1,2*
- *Corresponding Author:
- Ling Z
School of Information Science and Engineering
Changzhou Key Laboratory of Biomedical Information Technology
Changzhou 213164, China
E-mail: [email protected]
Received date: May 11, 2017; Accepted date: May 16, 2017; Published date: May 20, 2017
Citation: Zhuqing J, Huan W, Ling Z (2017) Modularization Analysis of Brain Functional Network Using Fuzzy C-means Algorithm and Correlation in Resting State. J Health Med Informat 8:255. doi: 10.4172/2157-7420.1000255
Copyright: © 2017 Zhuqing J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aiming to study the local functional structure of brain function network in resting state, the Fuzzy C-means (FCM) algorithm is adapted to modular the brain functional network. Then the nodes in module are connected into a network using correlation between the time series extracted from Functional Magnetic Resonance Imaging (fMRI) data. Afterwards node degree, clustering coefficient and shortest path length are used to analyse the functional characteristics of networks. Finally, the differences in activation between patients and normal controls’ brain regions are compared through Amplitude of Low Frequency Fluctuation (ALFF). Experimental results demonstrate that, the shortest path length of the patient is smaller than that of the normal human, so the information transmission rate increases. Clustering coefficient is higher than the normal, and the degree of grouping of network is enhanced. The correlation between the patient nodes is generally greater than the normal, and there is a weakened situation in the local area. It also found that the proportion of region for the activation level higher than the average of the whole brain in normal with more than the patient. In particular, the activation level of the Precentral gyrus (PreCG) and other regions in patient has a large degree decline. And the activation level in left Caudate nucleus (CAU.L), the lenticular nucleus, Putamen (PUT) and the lenticular nucleus, Palladium (PAL) and other regions is increased for patient. The research results verify the feasibility of modularization analysis of brain functional network using algorithm and correlation in resting state.