Modulating Efficiency of γ-Irradiated Rosemary in Improving the Hepatic Antioxidant Status of Ethanol Administrated Rats
R. G. Hamzaa*, A. N. El Shahat and H.M.S. Mekawey
Food Irradiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Nasr City, Cairo, Egypt
- *Corresponding Author:
- Refaat Galal Hamzaa
Department of Food Irradiation
National Centre for Radiation
Research and Technology (NCRRT)
Atomic Energy Authority
Nasr City, Cairo, Egypt
E-mail: [email protected]
Received Date: October 22, 2012; Accepted Date: November 19, 2012; Published Date: November 22, 2012
Citation: Hamzaa RG, EI Shahat AN, Mekawey HMS. (2012) Modulating Efficiency of γ-Irradiated Rosemary in Improving the Hepatic Antioxidant Status of Ethanol Administrated Rats. Biochem Anal Biochem 1:124. doi:10.4172/2161-1009.1000124
Copyright: © 2012 Hamzaa RG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Alcoholic liver disease represents a spectrum of clinical illness and morphological changes such as hepatic inflammation and necrosis (alcoholic hepatitis). Among natural antioxidants, rosemary contains several antioxidant oil and phenolic components that exhibit hepatoprotective effect. This study aimed to investigate the antioxidant effect of dietary supplementation with γ-irradiated rosemary in ethanol induced liver injury in rats. Rosemary essential oil was analyzed by gas chromatography/mass spectrometry (GC/MS). The results of biological study revealed that dietary supplementation of either raw or γ-irradiated rosemary following ethanol administration exerts remarkable modulating effect by reducing the level of total bilirubin, the activity of transaminases, gamma glutamyl transferase and serum alkaline phosphatase, decreasing the concentration of some lipid contents, malondialdehyde and xanthine oxidase activity. Also, supplementation of dietary rosemary resulted in elevation of high density lipoprotein level, reduced glutathione content and enhances the activity of xanthine oxidase dehydrogenase, superoxide dismutase and catalase. Thus, gamma-irradiated rosemary could be incorporated to the diet as a nutritional supplement, to augment the liver's defences against oxidative stress.