alexa Modulating the Glucose Transport by Engineering Gold Nanoparticles | OMICS International | Abstract
ISSN: 2155-983X

Journal of Nanomedicine & Biotherapeutic Discovery
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Research Article

Modulating the Glucose Transport by Engineering Gold Nanoparticles

Sanjib Bhattacharyya1,2*#, Krishna Kattel1,3# and Franklin Kim1

1WPI-Institute of Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8501, Japan

2WPI-Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai 980-8577, Japan

3University of Nebraska Medical Center, Nebraska, Omaha, NE 68198, USA

#Authors have equal contribution

*Corresponding Author:
Sanjib Bhattacharyya
WPI-AIMR (World Premier International Research Center Initiative (WPI)
MEXT, Japan and Advanced Institute for Materials Research)
Tohoku University, 2-1-1, Katahira
Aoba-ku, Sendai 980-8577, Japan
Tel: +819094707969
E-mail: [email protected]

Received date: April 08, 2016; Accepted date: April 26, 2016; Published date: April 30, 2016

Citation: Bhattacharyya S, Kattel K, Kim F (2016) Modulating the Glucose Transport by Engineering Gold Nanoparticles. J Nanomedine Biotherapeutic Discov 6:141. doi:10.4172/2155-983X.1000141

Copyright: © 2016 Bhattacharyya S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Gold Nanoparticles (GNP) have been widely used as a delivery vehicle for the targeted release of the drugs, vaccine and therapeutics. Literature evidence indicates that besides acting as a carrier, gold nanoparticles can alter the uptake mechanism of a targeting agent to the cancer cell. Therefore, designing a carrier plays a critical role to modulate various internalization pathways of a cargo. Given the role of malfunctioning reporter in various Mendelian diseases, it will be important to come up with a synthetic bio-mimetic transporter that can optimize the transport deficit. Glucose transport is impaired in hyperglycemia and glucose possibly faces identity crisis to enter into the cell. Using GNP for transport management of various metabolites is emerging. We have reported a design, synthesis and in vitro demonstration of an artificial Nano Glucose Transporter (NGT) to capture extracellular glucose and carry them to the cell when added exogenously, independent of endogenous cellular transporter pathways. This strategy could be extended for future application to the transport problems where extracellular biologic and metabolite burdens could be potential threat to the physiology.

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