Modulation Effects of Piracetam and Ginkgo Biloba on the Cognitive and Working Memory Functions: Psychometric StudyHayder M Alkuraishy*, Ali I Algareeb, Ali K Albuhadilly and Basim M Almgoter
Department Of Pharmacology, Toxicology and Medicine College of Medicine Almustansiriya University, Iraq
- Corresponding Author:
- Hayder M Alkuraishy
Department Of Pharmacology
Toxicology and Medicine College of Medicine Almustansiriya University
P.O. Box 14132 Iraq /Baghdad
Received date: August 26, 2014; Accepted dat: September 22, 2014; Published date: September 28, 2014
Citation: Alkuraishy H, Algareeb A, Albuhadilly A, Almgoter B (2014) Modulation Effects of Piracetam and Ginkgo Biloba on the Cognitive and Working Memory Functions: Psychometric Study. J Neurol Neurophysiol 5:234. doi:10.4172/2155-9562.1000234
Copyright: © 2014 Alkuraishy HM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Extracts of ginkgo biloba have been broadly prescribed toward advance symptoms of cognitive dysfunction
ranging in severity from mild memory loss to dementia also; in delaying the development of dementia; ginkgo biloba
has been encouraged commercially as a smart medicine to augment the brain function of healthy people. Piracetam
is a no tropic remedy correlated to inhibitory γ-aminobutyric acid (GABA) neurotransmitter. Piracetam may be the
initial agent acting on cognitive function without sedation. Thirty subjects (30 males) arbitrarily choose as of medical
college students. The contributors were allowable to perform mutually on the psychomotor performance device
tester and the computerized n-back test (working memory task) to obtain knowledge from those tests sooner than
the commencing of the examination. All psychometric response time and working memory test parameters
calculated previous to the experimental research, so the identical volunteers considered as control and through four
days of receiving the ginkgo biloba 60mg/day (trunature GSL),piracetam 800 mg/day (neutrophil) or both drugs so
the enrolled participants divided into three groups .Group A take ginkgo biloba, group B take piracetam and group C
take piracetam and ginkgo biloba.
Piracetam significantly improve cognitive and working memory at all levels P<0.05 while it showed insignificant
effects on psychometric reaction time parameters except it ameliorate the total reaction time (TRT) P <0.05. The
differential effects of ginkgo biloba showed significant effects on psychometric reaction time and cognitive central
Integrity P<0.05 and insignificant effects on working memory accuracy except at level ÃÂ-Back where it produced
significant effects P<0.05. Combined effects of ginko biloba and piracetam on psychomotor performances, cognitive
function and working memory produced significant effects P <0.05.
Conclusion: Combined effects of piracetam and ginkgo biloba produced more significant effects than either
ginkgo biloba or piracetam alone on cognitive function and working memory.