alexa Modulation of Angiogenesis and Immune Response in Canine Osteosarcoma by BMP-2 and Mesenchymal Stem Cells
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Research Article

Modulation of Angiogenesis and Immune Response in Canine Osteosarcoma by BMP-2 and Mesenchymal Stem Cells

Rici REG1,3*, Will SEA1, Favaron PO1, Fratini P1, Miglino MA1, Ambrósio CE2 and Maria DA3

1Department of Surgery, Faculty of the Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

2Laboratory of Animal Anatomy, Faculty of Animal and Food Engineering, University of Sao Paulo, Pirassununga, Sao Paulo, Brazil

3Laboratory of Biochemical and Biophisic, Butantan Institute, São Paulo, São Paulo, Brazil

*Corresponding Author:
Dr. Rose Eli Grassi Rici
Department of Surgery
Faculty of the Veterinary Medicine and Animal Science
University of São Paulo
São Paulo 05508-270, Brasil
Tel/Fax: 55-11-3091-7805
E-mail: [email protected]

Received date: June 25, 2013; Accepted date: August 19, 2013; Published date: August 21, 2013

Citation: Rici REG, Will SEA, Favaron PO, Fratini P, Miglino MA, et al. (2013) Modulation of Angiogenesis and Immune Response in Canine Osteosarcoma by BMP-2 and Mesenchymal Stem Cells. J Stem Cell Res Ther 3:143. doi:10.4172/2157-7633.1000143

Copyright: © 2013 Rici REG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Osteosarcoma is the most frequent bone tumor that predominantly targets the adolescent aged between 10- 25 years. In the veterinary oncology, osteosarcoma accounts 80-95% of the bone tumors diagnosed in dogs. Humans and dogs share several similarities in regard to the physiological and molecular aspects of osteosarcoma development. For this reason dogs have been used as a homologous model to human, which have been showed promising in vitro results. Herein, from implanted tumor in nude mice we analyzed the effects of a combination of stem cells from canine bone marrow and bone morphogenetic protein (BMP-2) on the treatment of osteosarcoma. The results showed that this combination changed the expression of markers of cell death, leading to an increase of caspase 3 expression, and decreased of Bcl-2 expression, as well as decreased in cell proliferation (Ki-67 and p53) and receptor of angiogenesis pathways (CD34, COX-2, IL-6, IL-8, and VEGF). The tumor environment was modified by decreased expression of CD4 + CD25 + resulting in increased CD8 + cytotoxic. In conclusion, these data showed that the treatment using the combination of stem cells from canine bone marrow and bone morphogenetic protein (BMP-2) emerges as a potential therapeutic tool for the osteosarcoma treatment.


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