alexa Modulation of Epigenetic Profiles in Traffic Workers Exposed to Car Fumes in Egypt | OMICS International| Abstract
ISSN: 2168-9547

Molecular Biology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
  • Research Article   
  • Mol Bio,
  • DOI: 10.4172/2168-9547.1000225

Modulation of Epigenetic Profiles in Traffic Workers Exposed to Car Fumes in Egypt

Shaat R1, Abdel-Ghany SE1, Nasr GM2, Sabit H3* and El-Zawahry M1,4
1College of Biotechnology, Misr University for Science and Technology, Giza, Egypt
2Department of Molecular Diagnostics, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City University, Egypt
3Department of Genetics, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Saudi Arabia
4Research and Development Center, Misr University for Science and Technology, Giza, Egypt
*Corresponding Author : Sabit H, Department of Genetics, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Saudi Arabia, Tel: +966546177974, Email: [email protected]

Received Date: Nov 21, 2018 / Accepted Date: Dec 04, 2018 / Published Date: Dec 13, 2018

Abstract

Air pollution is one of the most crucial public health concerns over the globe. Car fumes are major component of the pollution burden, and thought to modulate the methylation landscape of the exposed people. In the present investigation, 199 blood samples were collected from male traffic workers belonging to the Traffic Department, Ministry of Interior in Egypt. Global DNA methylation was quantified using real time PCR, and the obtained results indicated a hypermethylation in the outdoor group compared to the indoor group. Transforming growth factor (TGF-β) gene expression was assessed using real time PCR as an indicator for the transformation of cells from the normal to the malignant state. Data indicated that the outdoor group had an elevated level of TGF-β expression as normalized by β actin compared to the indoor group. Blood glucose was also reported an increased level in the outdoor compared to the indoor group. These data could be considered as a preliminary study to a larger one to underlie the risk of exposure to car fumes on traffic workers, especially the outdoor workers.

Keywords: Air pollution; Epigenetics; Methylation; TGF-β; Car Fumes; Egypt

Citation: Shaat R, Abdel-Ghany SE, Nasr GM, Sabit H, El-Zawahry M (2019) Modulation of Epigenetic Profiles in Traffic Workers Exposed to Car Fumes in Egypt. Mol Biol 8: 225. Doi: 10.4172/2168-9547.1000225

Copyright: © 2019 Shaat R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 685
  • [From(publication date): 0-0 - Oct 18, 2019]
  • Breakdown by view type
  • HTML page views: 623
  • PDF downloads: 62
Leave Your Message 24x7
Top