Journal of Bioengineering & Biomedical Science

Modulations of Neem Leaf Extract on Reproductive Hormones of Male Wistar Rats

Abstract

Aigbiremolen AA and Odigie MO

Reputable for treatment of Malaria, Diabetes, Digestive disorders, Fever, Wounds, Jaundice, and painful menstruation, Azadirachta indica (Neem) is locally called “Dogonyaro” in Nigeria and has been reported to be an orally active, safe, and effective plant preparation in fertility regulation. This study investigated the effect of neem leaf extract on male reproductive hormones in wistar rats. Eight wistar rats were divided into two groups of four rats each (n=4). While group 1 rats were fed normal mesh and water (Control), group 2 received 200 mg/kg body weight of neem extract and mesh feed (Extract). Following period of administration, rats were euthanized, and blood samples obtained for analysis of reproductive hormones [Testosterone, Follicle Stimulating Hormone (FSH), and Leutenizing Hormone (LH)]. Student’s t-test revealed a decrease in testosterone, FSH, and LH levels of experimental groups as compared with control. Study therefore has shown that neem leaf extract can negatively affect male reproductive hormones.