alexa Molecular Basis of Aging and Breast Cancer | OMICS International
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Review Article

Molecular Basis of Aging and Breast Cancer

Sandip K Mishra*, Debomita Sengupta, Pranati Sar and Dharmendra K Bhargava

Cancer Biology Lab, Department of Gene Function and Regulation, Institute of Life Sciences, Odisha, India

*Corresponding Author:
Sandip K Mishra
Scientist D, Institute of Life Sciences
Nalco Square, Chandrasekharpur
Bhubaneswar, 751023, India
Tel: 916742300702
Fax: +916742300728
E-mail: [email protected]

Received date: December 31, 2012; Accepted date: January 18, 2013; Published date: January 21, 2013

Citation: Mishra SK, Sengupta D, Sar P, Bhargava DK (2013) Molecular Basis of Aging and Breast Cancer. J Cancer Sci Ther 5:069-074. doi:10.4172/1948-5956.1000187

Copyright: © 2013 Mishra SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Age is one of the most important risk factors for human malignancies, including breast cancer. In relation to
increase in breast cancer incidence, aging can significantly alter breast cancer biology as defined by validated
prognostic and predictive biomarkers. Despite awareness that breast cancer and other cancers are primarily agerelated
diseases, molecular and cellular hypothesis explaining the cancer-aging relationship have only recently
emerged and remain clinically unproven. Here we review the series of key observations that has led to complex but
growing convergence between our understanding of the biology of aging and the mechanisms underlying breast
cancer occurrence.

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