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ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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  • Research Article   
  • J Mol Genet Med 2019, Vol 13(2): 417

Molecular Characterization of Spitz Tumors: An Approach to Improve Disease Diagnosis and Classification

Giubellino A1,2* and Zhou Y1,2*
1Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware St. SE, C516 Mayo Minneapolis, USA
2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
*Corresponding Author (s) : Dr. Giubellino A, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware St. SE, C516 Mayo Minneapolis, MN, 55455, USA, Tel: 612 273 5920, Fax: 612 273 1142, Email: [email protected]
Dr. Zhou Y, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware St. SE, C516 Mayo Minneapolis, MN, 55455, USA, Tel: 612 273 5920, Fax: 612 273 1142, Email: [email protected]

Received Date: Mar 19, 2019 / Accepted Date: Mar 26, 2019 / Published Date: Apr 02, 2019

Abstract

Spitz neoplasms are relatively uncommon melanocytic lesions characterized by an epithelioid or spindled cell morphology and present more commonly in younger age. They represent a spectrum from benign to malignant lesions which sometime represent a diagnostic conundrum. Recent advances in the genetic characterization of these lesions allow a better classification with consequent improvement in diagnostic accuracy and patient management. This review aims at summarizing our recent understanding of these lesions at the molecular level.

Keywords: Spitz tumor; Spitz nevus; Spitzoid neoplasm; Atypical spitz tumor; Spitzoid melanoma

Citation: Giubellino A, Zhou Y (2019) Molecular Characterization of Spitz Tumors: An Approach to Improve Disease Diagnosis and Classification. J Mol Genet Med 13:417.

Copyright: © 2019 Giubellino A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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