alexa Molecular Docking of HIV-1 env gp120 Using Diterpene Lactones from <em>Andrographis paniculata</em> | OMICS International| Abstract

ISSN: 2161-0401

Organic Chemistry: Current Research

  • Research Article   
  • Organic Chem Curr Res,
  • DOI: 10.4172/2161-0401.1000150

Molecular Docking of HIV-1 env gp120 Using Diterpene Lactones from Andrographis paniculata

Kabir OO*, Abdulfatai TA and Akeem AJ
Chemistry Unit, Department of Chemical, Geological and Physical Sciences, Kwara State University, Malete, Ilorin, Nigeria
*Corresponding Author : Kabir OO, Chemistry Unit, Department of Chemical, Geological and Physical Sciences, Kwara State University, PMB 1530, Ilorin, Nigeria, Tel: 2348066760669, Email: [email protected]

Received Date: Aug 11, 2015 / Accepted Date: Sep 21, 2015 / Published Date: Sep 28, 2015

Abstract

The search for effective drugs to treat HIV/AIDS has been the major task of most researchers since several years of its discovery. Most synthetic drugs such as Efavirenz, Tenofovir, Emtricibatine among others are employed in the antiretroviral treatment which have dangerous effects on patients. Thus, herbal medicine can be used as an alternative source of treatment for HIV positive patients as they exhibit little or no side effects when compared to synthetic drugs. This research work sought to examine whether plant diterpene lactones isolated from Andrographis paniculata exhibit anti-HIV activity using molecular docking studies. The HIV-1 env gp120 was docked by two diterpene lactones namely; andrographolide and neoandrographolide using docking tool (igemdock v2.1) after retrieving protein structure from Protein Data Bank (PDB). The result indicates that neoandrographolide is a more promising drug against HIV-1 than andrographolide due to its low interaction energy for the formation of ligand-receptor complex.

Keywords: Andrographolide; Env gp120; HIV-1; Docking; PDB

Citation: Kabir OO, Abdulfatai TA, Akeem AJ (2015) Molecular Docking of HIV-1 env gp120 Using Diterpene Lactones from Andrographis paniculata. Organic Chem Curr Res 4: 150. Doi: 10.4172/2161-0401.1000150

Copyright: © 2015 Kabir OO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment
Share This Article
Relevant Topics
Recommended Conferences
  • International conference on Organic Farming & Biological Treatment

    September 19-20, 2018 Dallas, USA

  • 10th Europian Organic Chemistry Congress

    March 21-22, 2019 Rome, Italy

Viewmore
Article Usage
  • Total views: 12005
  • [From(publication date): 9-2015 - Jul 21, 2018]
  • Breakdown by view type
  • HTML page views: 8176
  • PDF downloads: 3829
Leave Your Message 24x7