Molecular Â– Docking Studies of Potent Anticancer Agent
- *Corresponding Author:
- Heena V. Sanghani
Assistant Professor in Engineering
Chemistry Sinhgad College of Engineering
Vadgaon (Bk), Pune
E-mail: [email protected]
Received Date: September 20, 2011; Accepted Date: January 25, 2012; Published Date:January 27, 2012
Citation: Sanghani HV, Ganatra SH, Pande R (2012) Molecular -Docking Studies of Potent Anticancer Agent. J Comput Sci Syst Biol 5:012-015. doi:10.4172/jcsb.1000085
Copyright: © 2012 Sanghani HV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cyclin dependent kinases are critical molecules that control cell cycle progression from one phase to the other. However, mutational changes in these molecules lead to the purturbed cell cycle leading to uncontrolled cellular proliferation or cell death. In humans, mutations in cyclin dependent kinase 2 (1GII) is responsible for nearly 50% of cancers. In this paper preliminary in-silico screening were performed of natural polytriterpene phytochemical that are thought to have potential to inhibit mutated 1GII. Out of the two triterpenes boswellic acid and ursolic acid, boswellic acid shows inhibition activity with 1GII. From this study we propose that boswellic acid is promising towards oral cancer than ursolic acid.