Molecular Epidemiological Study of Hepatitis B Virus in the United Arab Emirates Based on the Analysis of Pre-S Gene
Mubarak S. Alfaresi*
Department of Pathology and Laboratory Medicine, Zayed Military Hospital, Abu Dhabi, UAE
- *Corresponding Author:
- Mubarak S. Alfaresi
Department of Pathology and Laboratory Medicine
Zayed Military Hospital, Abu Dhabi, UAE
Tel: +9712- 4055489
E-mail: [email protected]
Received Date: April 19, 2012; Accepted Date: June 24, 2012; Published Date: June 30, 2012
Citation: Alfaresi MS (2012) Molecular Epidemiological Study of Hepatitis B Virus in the United Arab Emirates Based on the Analysis of Pre-S Gene. J Med Microb Diagn 1:113. doi: 10.4172/2161-0703.1000113
Copyright: © 2012 Alfaresi MS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This study was undertaken to investigate the prevalence of the hepatitis B virus (HBV) variant with the pre-S mutant circulating in the United Arab Emirates (UAE). The sequences of the pre-S and S regions were determined in serum samples of 90 HBV DNA-positive subjects who had been enrolled in the study. The results showed that genotypes D and A accounted for 77.8% and 17.8% respectively. The distribution of the HBV antigen subtypes was: ayw2 (78.9%), adw2 (14.4%), and adw (2.2%). Sequencing analysis showed that pre-S mutations were present in 4 samples (4.4%), with pre-S2 deletion as the most common mutant (50%). The pre-S mutations were associated with older age and a higher mean HBV DNA level. The study demonstrated that HBV genotypes D and A were the predominant strains circulating in the UAE and that the HBV pre-S mutant is very rare in this area, appearing only in genotype C.