Molecular Mechanism of Tumorigenesis and Biomarkers of Opisthorchiasis-associated CholangiocarcinomaZhiliang Wu1* and Thidarut Boonmars2
- *Corresponding Author:
- Zhiliang Wu
Department of Parasitology
Gifu University Graduate School of Medicine
E-mail: [email protected]
Received date: March 04, 2013; Accepted date: May 28, 2013; Published date: June 07, 2013
Citation: Wu Z, Boonmars T (2013) Molecular Mechanism of Tumorigenesis and Biomarkers of Opisthorchiasis-associated Cholangiocarcinoma. J Bacteriol Parasitol 4:165. doi: 10.4172/2155-9597.1000165
Copyright: © 2013 Wu Z, et la. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Definitive relationship has been confirmed between Opisthorchis viverrini infection and tumorigenesis of cholangiocarcinoma (CCA), by epidemiological investigation and animal experiments. In the O. viverrini endemic area, opisthorchiasis-associated CCA has been becoming a serious public health problem. Understanding of the molecular mechanisms of tumorigenesis of the infection-induced CCA will be helpful to develop new biomarkers for diagnosis and therapy. This review addresses recent progresses in molecular mechanism and biomarker of opisthorchiasisassociated CCA.