alexa Molecular Pathways of Colorectal Carcinogenesis are Pro
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Review Article

Molecular Pathways of Colorectal Carcinogenesis are Promising Mistery?

Renata Dobrila Dintinjana1*, Arnela Redzović2 and Marijan Dintinjana1
1Department for Radiotherapy and Oncology,Clinical Hospital Centre Rijeka, Croatia
2Department of General Practice, Clinical Hospital Centre Rijeka, Croatia
Corresponding Author : Renata Dobrila Dintinjana
Department for Radiotherapy and Oncology
Clinical Hospital Center Rijeka
Krešimirova 42, 51000 Rijeka, Croatia
Tel: 00385 98 257 729
Fax: 00385 51 658 391
E-mail: [email protected]
Received December 02, 2013; Accepted April 17, 2014; Published April 25, 2014
Citation: Dintinjana RD, Redzovic A, Dintinjana M (2014) Molecular Pathways of Colorectal Carcinogenesis are Promising Mistery?. J Carcinog Mutagen S10:003. doi: 10.4172/2157-2518.S10-003
Copyright: © 2014 Dintinjana RD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The specific etiologic factors and pathogenetic mechanisms, underlying the development of cancers of the colon and rectum appear to be complex and

heterogeneous

. Despite the continuous advancement in diagnostic and therapeutic methods, despite the global and national programs for prevention it is evidenced increase in

colorectal cancer

(CRC) incidence and mortality.Further progress is needed in the field of non-invasive diagnostic methods to enable early diagnosis, pre and postoperative staging, and to assist in selecting the most suitable neo-adjuvant and adjuvant therapeutic methods and post-treatment follow-up. There are attempts to "personalise and individualise" anticancer therapy based on presence or absence of specific biomarkers. In this review we will focus on the prevalence, the latest progress made within the genomic and proteomic fields and their significance as possible prognostic and predictive markers in CRC patients.

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