alexa Molecular Targeted Therapies for Patients with Metastatic Renal Cell Cancer
ISSN: 2161-1025

Translational Medicine
Open Access

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Review Article

Molecular Targeted Therapies for Patients with Metastatic Renal Cell Cancer

Takeshi Yuasa1,2*, Yasuhisa Fujii1, Shunji Takahashi2, Iwao Fukui1 and Junji Yonese1

1Department of Urology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Tokyo, 135-8550, Japan

2Department of Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Tokyo, 135-8550, Japan

*Corresponding Author:
Takeshi Yuasa
Department of Urology and Medical Oncology
Cancer Institute Hospital
Japanese Foundation for Cancer Research
Tokyo, 138-8550, Japan
Tel: 81-3-3520-0111
Fax: 81-3570-0343
E-mail: [email protected]

Received Date: January 25, 2012; Accepted Date: February 01, 2012; Published Date: February 03, 2012

Citation: Yuasa T, Fujii Y, Takahashi S, Fukui I, Yonese J (2012) Molecular Targeted Therapies for Patients with Metastatic Renal Cell Cancer. Translational Medic S2:003. doi:10.4172/2161-1025.S2-003

Copyright: © 2012 Yuasa T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Major breakthroughs have occurred recently in the knowledge of the genetics and transduction pathways involved in various malignancies, including renal cell cancer (RCC). Novel targeted therapies directed against angiogenesis and the mammalian target of rapamycin (mTOR) pathway is now being developed for the treatment of metastatic RCC. Currently, four anti-angiogenesis agents, (sorafenib, sunitinib, bevacizumab, pazopanib) and two specific inhibitors of the mTOR kinase (temsirolimus and everolimus) are approved by the United States Food and Drug Administration. Moreover, at least three other tyrosine kinase inhibitors (TKI) (axitinib from Pfizer, tivozanib from AVEO Pharmaceuticals, and dovitinib from Novartis) are in advanced stages of clinical trials. Here, we will discuss the molecular targeted agents for RCC patients in clinical trials as well as in clinical practice.

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