Molecular Targeted Therapies Using Botanicals for Prostate Cancer Chemoprevention
- *Corresponding Author:
- Nagi B. Kumar
Division of Interdisciplinary Oncology
H. Lee Moffitt Cancer Center & Research Institute at the
University of South Florida College of Medicine
12902 Magnolia Drive, Tampa, Florida, USA, 33612
E-mail: [email protected]
Received Date: December 12, 2012; Accepted Date: December 27, 2012; Published Date: December 31, 2012
Citation: Nagi Kumar, Chornokur G (2012) Molecular Targeted Therapies Using Botanicals for Prostate Cancer Chemoprevention. Transl Med S2:005. doi:10.4172/2161-1025.S2-005
Copyright: © 2012 Nagi Kumar, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In spite of the large number of botanicals demonstrating promise as potential cancer chemopreventive agents, most have failed to prove effectiveness in clinical trials. Critical requirements for moving botanical agents to recommendation for clinical use include adopting a systematic, molecular-target based approach and utilizing the same ethical and rigorous methods that are used to evaluate other pharmacological agents. Preliminary data on a mechanistic rationale for chemoprevention activity as observed from epidemiological, in vitro and preclinical studies, phase I data of safety in suitable cohorts, duration of intervention based on time to progression of pre-neoplastic disease to cancer and using a valid panel of biomarkers representing the hypothesized carcinogenesis pathway for measuring efficacy must inform the design of clinical trials. Botanicals have been shown to influence multiple biochemical and molecular cascades that inhibit mutagenesis, proliferation, induce apoptosis, suppress the formation
and growth of human cancers, thus modulating several hallmarks of carcinogenesis. These agents appear promising in their potential to make a dramatic impact in cancer prevention and treatment, with a significantly superior safety profile than most agents evaluated to date. The goal of this paper is to provide models of translational research based on the current evidence of promising botanicals with a specific focus on targeted therapies for PCa chemoprevention.