alexa Molecular Targeting Therapy and Biomarker for Advanced Gastric Cancer | OMICS International | Abstract
ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
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Review Article

Molecular Targeting Therapy and Biomarker for Advanced Gastric Cancer

Kohei Shitara*, Toshihiko Doi and Atsushi Ohtsu
Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan
Corresponding Author : Kohei Shitara
Department of Gastroenterology and Gastrointestinal Oncology
National Cancer Center Hospital East, 6-5-1
Kashiwanoha, Kashiwa, Chiba 277-8577, Japan
Tel: 81-47-133-1111
Fax: 81- 47-134-6928
E-mail: [email protected]
Received July 02, 2012; Accepted July 20, 2012; Published July 23, 2012
Citation: Shitara K, Doi T, Ohtsu A (2012) Molecular Targeting Therapy and Biomarker for Advanced Gastric Cancer. J Phys Chem Biophys 2:107. doi:10.4172/2161-0398.1000107
Copyright: © 2012 Shitara K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In recent years, various molecular target agents have been investigated for gastric cancer. Main targets are HER family pathway, angiogenesis system and PI3K-Akt-mTOR intracellular signaling system. The anti-HER2 antibody trastuzumab was shown to prolong the survival of patients with HER2-positive advanced gastric cancer, and is approved by the treatment in advanced gastric cancer. On the other hand, the anti-VEGF antibody bevacizumab could not show survival benefit despite certain effect in progression-free survival and response rate. mTOR inhibitor everolimus showed disease control rate of 54.7% in patients with previously treated gastric cancer in a Japanese phase II trial. However, subsequent global phase III trial, GRANITE-1, which compare everolimus with placebo, could not meet its primary endpoint of overall survival. Recent REAL-III trial also could not show survival benefit of EGFR antibody panitumumab. These three negative phase III trials strongly suggest the importance of developing biomarkers to predict the effectiveness of each agent.

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