alexa Molecular-Genetic Polymorphisms of Dopamine, Serotonin
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

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Research Article

Molecular-Genetic Polymorphisms of Dopamine, Serotonin and Androgenic Systems as Molecular Markers of Success in Judo Wrestling Sportsmen

Polina R Butovskaya1,2, Marina L Butovskaya3, Vasiliy A Vasilyev2, Oleg E Lazebny4*, Dmitri V Shibalev2, Elizaveta V Veselovskaya3, Irina G Udina1and Alexey P Ryskov2

1Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, Russian Federation

2Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russian Federation

3Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow, 119991, Russian Federation

4Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russian Federation

*Corresponding Author:
Oleg E Lazebny
Kol’tsov Institute of Developmental Biology
Russian Academy of Sciences
Russian Federation
Tel: 749-913-587-81
Fax: 7-499-135-8012
E-mail: [email protected]

Received Date: February 27, 2013; Accepted Date: March 23, 2013; Published Date: March 26, 2013

Citation: Butovskaya PR, Butovskaya ML, Vasilyev VA, Lazebny OE, Shibalev DV, et al. (2013) Molecular-Genetic Polymorphisms of Dopamine, Serotonin and Androgenic Systems as Molecular Markers of Success in Judo Wrestling Sportsmen. J Bioanal Biomed S3:005. doi:10.4172/1948-593X.S3-005

Copyright: © 2013 Butovskaya PR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In this study we tested gene-candidates, associated with the stress-resistance and personality traits, aggression in particular, in 16 world-class judo sportsmen, and 40 young men as a control sample from general Russian population (all men were of Caucasian origin). The polygenic profile with 9 candidate genes which included 10 polymorphisms (i.e., AR, DRD4, DRD2, DAT1, COMT, 5-HTTL, MAOA, HTR1A and HTR2A) connected to the functioning of serotonin, dopamine, and androgenic systems were determined. It was demonstrated that judo sportsmen significantly differed from the control group by higher frequencies of AR alleles with lower numbers of CAG repeats, V/V genotype of COMT gene, and G/G genotype of HTR1A gene, thus suggesting these polymorphisms as genetic markers of sportive success in wrestling.


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