Mollaret Meningitis with High Level of Cytokines in CSF Successfully Treated by Indomethacin
Received Date: May 13, 2018 / Accepted Date: May 29, 2018 / Published Date: May 31, 2018
A rare case of Mollaret meningitis characterized by four recurrent episodes of aseptic meningitis during the 3-year periods were reported. The patient showed high fever and severe headache accompanied by high level of cerebrospinal fluid (CSF) cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alfa (TNF-a). The symptoms and high CSF cytokines were dramatically resolved immediately after inducing indomethacin treatment. Reactivation of the latent virus is considered to be the cause of this rare disease and indomethacin is estimated to inhibit periodic abnormal generation of eicosanoid in the brain resulting in reducing fever and subsequent inflammation.
Keywords: Mollaret meningitis; Recurrent aseptic meningitis; Fever; Indomethacin; Cytokines
Citation: Kawabori M, Kurisu K, Niiya Y, Ohta Y, Mabuchi S, et al. (2018) Mollaret Meningitis with a High Level of Cytokines in CSF Successfully Treated by Indomethacin. J Neurol Neurophysiol 9:464. Doi: 10.4172/2155-9562.1000464
Copyright: © 2018 Kawabori M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
- Total views: 1616
- [From(publication date): 0-2018 - Nov 18, 2019]
- Breakdown by view type
- HTML page views: 1567
- PDF downloads: 49