alexa Mollaret Meningitis with High Level of Cytokines in CSF Successfully Treated by Indomethacin | OMICS International| Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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  • Case Report   
  • J Neurol Neurophysiol,
  • DOI: 10.4172/2155-9562.1000464

Mollaret Meningitis with High Level of Cytokines in CSF Successfully Treated by Indomethacin

Masahito Kawabori1,2*, Kota Kurisu1, Yoshimasa Niiya1, Yuzuru Ohta1, Shoji Mabuchi1 and Kiyohiro Houkin2
1Department of Neurosurgery, Otaru General Hospital, , Japan
2Department of Neurosurgery, Hokkaido University Graduate School of Medicine, , Japan
*Corresponding Author : Masahito Kawabori, Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Japan, Tel: 81117065987, Fax: 81117087737, Email: [email protected]

Received Date: May 13, 2018 / Accepted Date: May 29, 2018 / Published Date: May 31, 2018


A rare case of Mollaret meningitis characterized by four recurrent episodes of aseptic meningitis during the 3-year periods were reported. The patient showed high fever and severe headache accompanied by high level of cerebrospinal fluid (CSF) cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alfa (TNF-a). The symptoms and high CSF cytokines were dramatically resolved immediately after inducing indomethacin treatment. Reactivation of the latent virus is considered to be the cause of this rare disease and indomethacin is estimated to inhibit periodic abnormal generation of eicosanoid in the brain resulting in reducing fever and subsequent inflammation.

Keywords: Mollaret meningitis; Recurrent aseptic meningitis; Fever; Indomethacin; Cytokines

Citation: Kawabori M, Kurisu K, Niiya Y, Ohta Y, Mabuchi S, et al. (2018) Mollaret Meningitis with a High Level of Cytokines in CSF Successfully Treated by Indomethacin. J Neurol Neurophysiol 9:464. Doi: 10.4172/2155-9562.1000464

Copyright: © 2018 Kawabori M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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