alexa Monitoring Enoxaparin with Antifactor Xa Levels in Seve
ISSN: 2376-0419

Journal of Pharmaceutical Care & Health Systems
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Research Article

Monitoring Enoxaparin with Antifactor Xa Levels in Severe Renal Impairment

Jose A Vega1*, Young R Lee1, Danni McMahan2 and Hanh-Nhi Q Duong3

1Adult Medicine Division, School of Pharmacy, Texas Tech University Health Sciences Center. Abilene, TX, USA

2PGY1 Pharmacy Resident, VA North Texas Health Care System Dallas, TX, USA

3Clinical Pharmacist, St. Luke’s The Woodlands Hospital. The Woodlands, TX, USA

Corresponding Author:
Jose A Vega
Department of Pharmacy Practice
School of Pharmacy Texas Tech University Health Sciences Center 1718 Pine Street
Abilene, TX 79601, USA
Tel: 325 / 696-0448
Fax: 325/676-3824
E-mail: [email protected]

Received date: June 02, 2016; Accepted date: June 20, 2016; Published date: June 24, 2016

Citation: Vega JA, Lee YR, McMahan D, Duong HQ (2016) Monitoring Enoxaparin with Antifactor Xa Levels in Severe Renal Impairment. J Pharma Care Health Sys 3:161. doi:10.4172/2376-0419.1000161

Copyright: © 2016 Jose A Vega, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Backgrounds: While several large clinical trials have proven the efficacy and safety of treatment with enoxaparin, most of these studies excluded patients with severe renal impairment and to date no large randomized studies have been conducted that assess the safety and efficacy of the drug in this subset of patients. Objectives: To characterize antifactor Xa peak levels as therapeutic, subtherapeutic, or supratherapeutic, in nondialysis patients with severe renal impairment who are receiving renally adjusted therapeutic doses of enoxaparin and to assess the incidence of bleeding complications in these patients. Methods: Retrospective cohort study in a community hospital evaluating seventy-five severe renal impairment patients (creatinine clearance [CrCl] < 30 mL/min) who received at least three renally adjusted therapeutic doses of enoxaparin and had steady-state antifactor Xa peak levels collected between April 2009 and April 2015. Institutional review board approval was obtained to collect data from patients' medical records. The primary outcome was the proportion of patients whose steady-state antifactor Xa peak levels were in the therapeutic, subtherapeutic, or supratherapeutic ranges. The secondary outcome was the incidence of major bleeding. Results: The final analysis showed that 63% of patients (n=47) had therapeutic levels, 22% (n=17) had subtherapeutic levels, and 15% (n=11) had supratherapeutic levels. No major bleeding incidents identified in the study. Conclusion: Based on the results of this study, monitoring antifactor Xa levels is warranted to ensure the safety and efficacy of renally adjusted doses of therapeutic enoxaparin in non-dialysis patients with severe renal impairment.

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