alexa Monthly Risedronate for the Treatment of Postmenopausal
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Monthly Risedronate for the Treatment of Postmenopausal Osteoporosis

Jun Iwamoto*

Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan

*Corresponding Author:
Jun Iwamoto
Institute for Integrated Sports Medicine
Keio University School of Medicine
35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Tel: +81-3-3353-1211
Fax: +81-3-3352-9467
E-mail: [email protected]

Received date: January 20, 2014; Accepted date: Fubruary 24, 2014; Published date: Fubruary 28, 2014

Citation: Iwamoto J (2014) Monthly Risedronate for the Treatment of Postmenopausal Osteoporosis. Pharm Anal Acta 5:285. doi: 10.4172/2153-2435.1000285

Copyright: © 2014 Iwamoto J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Risedronate is a first-line medicine for the treatment of postmenopausal osteoporosis, since meta-analyses of large randomized controlled trials have demonstrated its efficacy against vertebral, nonvertebral, and hip fractures. Risedronate has desirable pharmacological characteristics in terms of its low affinity for bone, and its strong inhibition of farnesyl pyrophosphate synthase rapidly reduces bone turnoverand reverses the effect. Monthly risedronate, which has been recently approved, is non-inferior to daily risedronate in terms of changes in surrogate markers and the incidence of adverse effects. However, the incidence of acute phase reactions is higher for a monthly dosing regimen than for a daily dosing regimen. Because monthly bisphosphonates are superior to weekly bisphosphonates in terms of patient preference and convenience and, consequently, treatment adherence (particularly persistence), monthly risedronate is considered to be useful in clinical practice

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