alexa Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes

Gianmattia del Genio1*, Carla Ferreri2, Raffaele Marfella1, Dimitri Pournaras3, Carel W le Roux2,4, Federica del Genio5, Limongelli Paolo1, Salvatore Tolone1, Ludovico Docimo1 and Annibale Alessandro Puca6

1Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy

2ISOF, Consiglio Nazionale delle Ricerche, Bologna, Italy

3Investigative Science, Imperial College London, UK

4Diabetes Complications Research Centre, UCD Conway Institute, University College Dublin, Ireland

5Center of Esophago-gastric and Bariatric Surgery (E.G.O.), Clinica C.G. Ruesch, Napoli, Italy

6IRCCS Multimedica, Milan, Italy; Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Italy

Corresponding Author:
Prof. Gianmattia del Genio
Division of Bariatric Surgery
Università degli studi di Napoli SUN
Via Pansini, 5 I-80131 Napoli, Italy
Tel: +393397008292
E-mail: [email protected]

Received Date: June 30, 2015; Accepted Date: July 16, 2015; Published Date: July 20, 2015

Citation: del Genio G, Ferreri C, Marfella R, Pournaras D, le Roux CW, et al. (2015) Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes. J Diabetes Metab 6:582. doi:10.4172/2155-6156.1000582

Copyright: © 2015 del Genio G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Morbid obesity is a pathologic condition associated to an increased incidence of several chronic conditions associated to increased risk of mortality. Erythrocyte fatty acid composition has been candidate as a biomarker of oxidative stress and consequently on the rate of aging and ultimately lifespan. To our knowledge, no study has investigated the total spectrum of lipid composition of erythrocyte membranes from obese individuals. The aim of this study was to compare the fatty acid composition of erythrocyte membranes derived from morbidly obese patients with healthy matched controls and long-living descendants. Methods: Gas chromatography was employed to determine fatty acid percentage of erythrocyte membranes from investigated groups. Results: Erythrocyte membranes from obese subjects had significantly lower percentage of monounsaturated fatty acids (16.0 ± 0.8 vs. 23.0 ± 4.5, p<0.01) and total trans fatty acid (0.2 ± 0.1 vs. 1.3 ± 1.2, p<0.001) than controls. Obese fatty acid profiles showed increased percent of total polyunsaturated fatty acid (36.5 ± 1.4 vs. 27.3 ± 10.9, p<0.001), polyunsaturated fatty acid n-3 (5.2 ± 0.9 vs. 2.6 ± 1.8, p <0.001) and n-6 (31.3 ± 1.7 vs. 25.0 ± 10.1, p<0.001). Interestingly, when obese fatty acid profiles are compared with long-living descendants, the former show opposite trends in the percentages of the main saturated and unsaturated residues of membrane phospholipids compared with nonagenarian offspring. Conclusion: This study shows that the erythrocyte membranes fatty acid composition of obese subjects differs from general population in a way opposite to the long-living descendants. If confirmed by further investigations, the fatty acid equilibration may become an additional target in the multidisciplinary strategy aimed to treat the obesity epidemic.


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