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Research Article

Morbidity of Diabetes Mellitus in Cynomolgus Monkeys

Saimei Yan1, Ting Wang1, Changhong Zhang2, Peng Wang2, Xiangting Xu2, Jihong Yang2,3*and Cui Yang1*
1Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, P.R. China
2School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, P.R. China
3Guangxi Weimei Biotechnology Co., Ltd., Nanning 530100, P.R. China
Corresponding Author : Cui Yang
Ethnic Drug Screening & Pharmacology Center
Key Laboratory of Chemistry in Ethnic Medicinal Resources
State Ethnic Affairs Commission & Ministry of Education
Yunnan Minzu University, Kunming 650500, China
Tel: +86-13698705584
E-mail: [email protected]
  Jihong Yang
School of Pharmaceutical Science & Yunnan Key
Laboratory of Pharmacology for Natural Products
Kunming Medical University, Kunming 650500
China
E-mail: [email protected]
Received January 07, 2015; Accepted February 03, 2015; Published February 12, 2015
Citation: Yan S, Wang T, Zhang C, Wang P, Xu X, et al. (2015) Morbidity of Diabetes Mellitus in Cynomolgus Monkeys. Biochem Pharmacol (Los Angel) 4: 163. doi:10.4172/2167-0501.1000163
Copyright: ©2015 Yan S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Object: To determine the morbidity of diabetes mellitus in cynomolgus monkey by performing the Oral Glucose Tolerance Test (OGTT).
Method: OGTTs were performed in 600 male cynomolgus monkeys, aging 4-18 years. The values of plasma glucose (PG) and insulin (Ins) were detected.
Result: Significant differences were found in the values of PG and Ins among groups with different ages. The values of PG of 4 pathological courses of DM were: Normal glucose tolerance (NGT) group: Fasting plasma glucose (FPG) < 6.10 mmol/L and 2hPG < 7.8 mmol/L; Impaired fasting glucose (IFG) group: 6.10 mmol/L ≤ FPG < 7.0 mmol/L and 2hPG < 7.8 mmol/L; Impaired glucose tolerance (IGT) group: FPG < 7.0 mmol/L and 7.8 mmol/L ≤ 2hPG < 11.1 mmol/L; diabetes mellitus (DM) group: FPG ≥ 7.0 mmol/L or 2hPG ≥ 11.1 mmol/L. The morbidity of diabetes mellitus in the tested cynomolgus monkeys was 11.5%.
Conclusion: Our findings pave the ways for a wide range of screening of DM in cynomolgus monkeys. Meanwhile, we also provide the reference to preclinically test new antidiabetic drugs in cynomolgus monkeys.

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