Morbidity of Diabetes Mellitus in Cynomolgus Monkeys
|Saimei Yan1, Ting Wang1, Changhong Zhang2, Peng Wang2, Xiangting Xu2, Jihong Yang2,3*and Cui Yang1*|
|1Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, P.R. China|
|2School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, P.R. China|
|3Guangxi Weimei Biotechnology Co., Ltd., Nanning 530100, P.R. China|
|Corresponding Author :||Cui Yang
Ethnic Drug Screening & Pharmacology Center
Key Laboratory of Chemistry in Ethnic Medicinal Resources
State Ethnic Affairs Commission & Ministry of Education
Yunnan Minzu University, Kunming 650500, China
E-mail: [email protected]
School of Pharmaceutical Science & Yunnan Key
Laboratory of Pharmacology for Natural Products
Kunming Medical University, Kunming 650500
E-mail: [email protected]
|Received January 07, 2015; Accepted February 03, 2015; Published February 12, 2015|
|Citation: Yan S, Wang T, Zhang C, Wang P, Xu X, et al. (2015) Morbidity of Diabetes Mellitus in Cynomolgus Monkeys. Biochem Pharmacol (Los Angel) 4: 163. doi:10.4172/2167-0501.1000163|
|Copyright: ©2015 Yan S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Object: To determine the morbidity of diabetes mellitus in cynomolgus monkey by performing the Oral Glucose Tolerance Test (OGTT).
Method: OGTTs were performed in 600 male cynomolgus monkeys, aging 4-18 years. The values of plasma glucose (PG) and insulin (Ins) were detected.
Result: Significant differences were found in the values of PG and Ins among groups with different ages. The values of PG of 4 pathological courses of DM were: Normal glucose tolerance (NGT) group: Fasting plasma glucose (FPG) < 6.10 mmol/L and 2hPG < 7.8 mmol/L; Impaired fasting glucose (IFG) group: 6.10 mmol/L ≤ FPG < 7.0 mmol/L and 2hPG < 7.8 mmol/L; Impaired glucose tolerance (IGT) group: FPG < 7.0 mmol/L and 7.8 mmol/L ≤ 2hPG < 11.1 mmol/L; diabetes mellitus (DM) group: FPG ≥ 7.0 mmol/L or 2hPG ≥ 11.1 mmol/L. The morbidity of diabetes mellitus in the tested cynomolgus monkeys was 11.5%.
Conclusion: Our findings pave the ways for a wide range of screening of DM in cynomolgus monkeys. Meanwhile, we also provide the reference to preclinically test new antidiabetic drugs in cynomolgus monkeys.