Morphogenesis of Metaplastic Changes in Gastroesophageal Reflux Disease
|Kilessa AV1* and Filonenko TG2
|1Assistant of Internal Medicine, Clinic of Crimean State Medical University by Georgiyevskiy S.I. Ukraine
|2Department of Pathomorphology, Crimean State Medical University by Georgiyevskiy S.I. Ukraine
|*Corresponding Author :
Assistant of Internal Medicine
Clinic of Crimean State Medical University by Georgiyevskiy S.I. Ukraine
E-mail: [email protected]
|Received July 05, 2013; Accepted August 22, 2013; Published August 28, 2013
|Citation: Kilessa AV, Filonenko TG (2013) Morphogenesis of Metaplastic Changes in Gastroesophageal Reflux Disease. Intern Med 3:125. doi:10.4172/2165-8048.1000125
|Copyright: © 2013 Kilessa AV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The aim of research is studying of morphogenesis
of metaplastic changes in esophageal mucous and defining diagnostic and prognostic criteria in Barrett Esophagus (BE) disease.
Materials for histological and immunnohistochemical research were mucosal biopsies of distal esophagus received from 79 patients with clinical and endoscopic indicators of BE. Immunohistochemical research with using markers CK7 and CK20 is characterized by high sensitivity, specificity and accuracy allowing defining a phenotype of various types of metaplastic processes at endoscopically defined Barrett’s Esophagus.
Moderate CK 20 expression CK20, high level of Ki67 expression and P53 in mucous epithelium of cardial type testifies about transformation of cylindrical gastric epithelium in intestinal that confirms existence of a transition form of metaplasia in intestinal and can be a precursory diagnostic symptom of Barret’s Esophagus development.
Markers Ki67 and P53 are predictors of dysplastic and malignant cell’s regeneration due to gradual increase in its expression with the maximal values in biopsies of adenocarcinoma