alexa Morphological Changes in Gastric Cancer after Helicobac
ISSN: 2165-8048

Internal Medicine: Open Access
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Case Series

Morphological Changes in Gastric Cancer after Helicobacter pylori Eradication Therapy

Tsutomu Namikawa1*, Sunao Uemura1, Satoru Tamura2, Michiya Kobayashi1 and Kazuhiro Hanazaki1
1Department of Surgery, Kochi Medical School, Japan
2Division of Gastroenterology, Tamura Clinic, Japan
*Corresponding Author : Tsutomu Namikawa
Department of Surgery, Kochi Medical School
Kohasu, Oko-cho, Nankoku, Kochi, Japan
Tel: 81888802370
E-mail: [email protected]
Received April 29, 2015; Accepted May 14, 2015; Published May 21, 2015
Citation: Namikawa T, Uemura S, Tamura S, Kobayashi M, Hanazaki K (2015) Morphological Changes in Gastric Cancer after Helicobacter pylori Eradication Therapy. Intern Med 5:194. doi:10.4172/2165-8048.1000194
Copyright: © 2015 Namikawa T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


A 63-year-old woman visited her local doctor complaining of acid regurgitation. Esophagogastroduodenoscopy revealed a protruding lesion with a modulated mucosal surface in the gastric antrum, with mucosal biopsies indicating well-differentiated adenocarcinoma. Because of a positive urea breathe test, while the patient was waiting for elective surgery she underwent Helicobacter pylori eradication therapy. Thirty days after eradication therapy, the patient underwent laparoscopic distal gastrectomy with regional lymph node dissection. Gross examination of the resected specimen revealed a well-circumscribed, slightly depressed lesion measuring 3.0 × 2.0 cm without elevated components. Direct effects of H. pylori eradication therapy on the morphological appearance of gastric adenomas and carcinomas have been reported. The findings in this patient suggest that the morphology of gastric cancer may be influenced directly by H. pylori eradication therapy.

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