alexa Morphometrical, Histopathological, and Cytogenetical Ameliorating Effects of Green Tea Extract on Nicotine Toxicity of the Testis of Rats
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Research Article

Morphometrical, Histopathological, and Cytogenetical Ameliorating Effects of Green Tea Extract on Nicotine Toxicity of the Testis of Rats

Azza M Gawish1*, Sherin Ramadan1, Aziza M Hassan2 and Aliaa M Issa3

1Department of Zoology, Faculty of Science, Cairo University, Dokki, Giza, Egypt

2National Research Centre, Cell biology Department, Dokki, Giza, Egypt

3National Organization for Drug control and Research, Dokki, Giza, Egypt

*Corresponding Author:
Azza M Gawish
Department of Zoology
Faculty of Science, Cairo University
Dokki, Giza, Egypt
E-mail: [email protected]

Received date: October 05, 2010; Accepted date: November 22, 2010; Published date: November 24, 2010

Citation: Gawish AM, Ramadan S, Hassan AM, Issa AM (2010) Morphometrical, Histopathological, and Cytogenetical Ameliorating Effects of Green Tea Extract on Nicotine Toxicity of the Testis of Rats. J Cytol Histol 1:105. doi: 10.4172/2157-7099.1000105

Copyright: © 2010 Gawish AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



This current study aimed at evaluating the toxic effect of nicotine and the possible protective role of green tea extract on some organs of Swiss albino mice by using histological, histomorphometerical a nd cytogenetical studies. Male Swiss albino mice were divided into four groups. The first group served as control and was injected intrapertoneally (i.p.) with distilled water (1ml DW/daily). The second group was injected with green tea extract (40 mg/ kg.b.w./i.p./ daily), animals of the third group were injected with nicotine (2.5 mg/kg.b.w./i.p. daily) and those of the fourth group were injected with nicotine (2.5 mg/kg.b.w./i.p/daily) and green tea extract (40 mg/ kg.b.w./i.p./daily). The experimental period was four successive weeks. Nicotine treatment induced histological changes in both the lung and testicular tissue as revealed by light microscope. It also induced histomorphological changes in the lung represent by significant decrease in elastic fibers and in the testicular tissue, a significant decrease in the number of Leydig cells. These changes were obtained by the computer image analyser. Combine administration of nicotine with green tea extract resulted in marked ameliorations of the testicular changes using histological and histomorphological observations. The combine administration of nicotine with green tea extract caused also an improvement in the ratio of PCEs/NCEs and a significant decrease in the increase of the MnPCEs numbers induced by nicotine treatment alone. In conclusions, the administration of green tea extract might suppress the cytotoxicity and mutagenic activity of nicotine. We suggest that green tea extract may be useful in combating tissue injury and genotocity caused by nicotine toxicity.


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