Most T Cells in Human Neonatal Skin are Not Naive
Johnnie Akgün, Marion Prior and Adelheid Elbe-Bürger*
Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases (DIAID), Laboratory of Cellular and Molecular Immunobiology of the Skin, Medical University of Vienna, Vienna, Austria, Europe
- *Corresponding Author:
- Adelheid Elbe-Bürger
PhD, Associate Professor, Medical University of Vienna
Department of Dermatology, DIAID, Währinger Gürtel 18-20
Room Nr. 4P904, 1090 Vienna, Austria, Europe
E-mail: [email protected]
Received date: November 15, 2011; Accepted date: January 16, 2012; Published date: January 20, 2012
Citation: Akgün J, Prior M, Elbe-Bürger A (2012) Most T Cells in Human Neonatal Skin are Not Naïve. J Clin Exp Dermatol Res S2:004. doi: 10.4172/2155-9554.S2-004
Copyright: © 2012 Akgün J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
T cells present in human skin are involved in cutaneous immune surveillance but can also contribute actively to inflammatory skin diseases. In healthy human adult skin, T cells mainly belong to the CD45RO+ memory population. In contrast, human fetal skin contains predominantly CD45RA+ naive T cells. In this study, we elucidated the T cell composition in human skin samples after birth to unravel whether the change of the microenvironment influences the cutaneous T cell repertoire. Double-immunofluorescence staining on skin cryostat sections revealed that the majority of CD3+ T cells in human neonatal epidermis as well as dermis displayed a memory phenotype and that their numbers
progressively increased with age. While naive T cells were observed in neonatal dermis, these cells were not present in neonatal epidermis. Some rare naive T cells appeared in infant epidermis. Taken together our results show that the composition of T cells in human neonatal skin is comparable in some aspects to adult as well as fetal skin and shows that the change of the microenvironment is accompanied by an altered T cell arrangement of the skin.