alexa Mouse Experimental Models of Atherosclerosis in Pharmacology
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

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Review Article

Mouse Experimental Models of Atherosclerosis in Pharmacology

Jacek Jawien*
Associate Professor, Chair of Pharmacology, Jagiellonian University School of Medicine, Grzegorzecka Str. 16, Krakow, Poland
Corresponding Author : Jacek Jawien
Associate Professor
Chair of Pharmacology
Jagiellonian University School of Medicine
Grzegorzecka Str. 16, Krakow, Poland
Fax: +48 12 4217217
E-mail: [email protected]
Received July 29, 2011; Accepted September 06, 2011; Published September 16, 2011
Citation: Jawien J (2011) Mouse Experimental Models of Atherosclerosis in Pharmacology. J Clinic Experiment Cardiol S1:001. doi: 10.4172/2155-9880.S1-001
Copyright: © 2011 Jawien J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The mouse has become an excellent model for experimental atherosclerosis research. Until 1992, the diet - induced atherosclerosis mouse model has been used effectively, but the lesions tended to be small and were limited to early fatty-streak stage. This model was also criticized because of the toxicity and inflammatory responses due to the diet. In 1992 the first line of gene targeted animal models, namely apolipoprotein E - knockout mice was developed. Of the genetically engineered models, the apoE - deficient model is the only one that develops extensive atherosclerotic lesions on a chow diet. It is also the model in which the lesions have been characterized most thoroughly. The lesions develop into fibrous plaques; however, there is no evidence that plaque rupture occurs in this model. The LDL receptor - deficient model has elevated LDL levels, but no lesions, or only very small lesions, form on the chow diet, however, robust lesions do form on the western type diet. The creation of apoE - knockout mice has changed the face of atherosclerosis research.

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