Moving in and Out: Dispersion of Cells in Self-Generated Gradients
Christina H. Stuelten*
National Institutes of Health, National Cancer Institute, Laboratory of Cellular and Molecular Biology, 37 Convent Drive, Bethesda, MD 20892, USA
- *Corresponding Author:
- Christina H. Stuelten
National Institutes of Health, National Cancer Institute
Laboratory of Cellular and Molecular Biology
37 Convent Drive, Bethesda, MD 20892, USA
E-mail: [email protected]
Received date: May 03, 2017; Accepted date: May 18, 2017; Published date: May 29, 2017
Citation: Stuelten CH (2017) Moving in and Out: Dispersion of Cells in Self-Generated Gradients. J Clin Cell Immunol 8:507. doi: 10.4172/2155-9899.1000507
Copyright: © 2017 Stuelten CH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Migrating cells can influence the direction of their own migration by metabolizing chemoattractants present in their environment. This is illustrated by the dispersal of melanoma cells, which break down lysophosphatidic acid and generate a gradient with increasing concentrations of lysophosphatidic acid distant from the tumor. Melanoma cells can then disperse away from the tumor as they migrate in the self-generated lysophosphatidic acid gradient. Thus, dispersal of tumor cells during invasion of the surrounding stroma might be driven by chemotaxis of cells along self-generated chemoattractant gradients.