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ISSN: 2329-6895

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Research Article

MRI Characterizations of Region Specific White Matter Hyperintensities and Vertebral Artery Stenosis

Liya Wang1,2, Adrian Lam3, John Oshinski1,2 , Xiaodong Zhong4, Chad A Holder1, Felicia Goldstein5, Diana Ge2 and Hui Mao1,2*
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
2Center for Systems Imaging, Emory University, Atlanta, Georgia, USA
3Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
4MR R&D Collaborations, Siemens Healthcare, Atlanta, Georgia, USA
5Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
Corresponding Author : Hui Mao, PhD
Professor, Department of Radiology and Imaging Sciences
Emory University School of Medicine
Atlanta, Georgia, USA
Tel: 404-712-0357
E-mail: [email protected]
Received June 20, 2014; Accepted August 14, 2014; Published August 18, 2014
Citation: Wang L, Lam A, Oshinski J, Zhong X, Holder CA, et al. (2014) MRI Characterizations of Region Specific White Matter Hyperintensities and Vertebral Artery Stenosis. J Neurol Disord 5:178. doi: 10.4172/2329-6895.1000178
Copyright: © 2014 Wang L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Cerebrovascular diseases cause brain degeneration and subsequent decline of cognitive functions. In this study, comprehensive magnetic resonance imaging approaches with both structural and blood flow imaging were used to characterize the white matter hyperintensity in the brain, cerebral blood flow, and obstruction of vertebral artery caused by stenosis in various cases of individuals with cerebral vascular and cardiovascular risks. It is demonstrated that vertebral artery stenosis characterized as vertebral artery narrowing and/or reduced blood flow velocity by MRI may be associated with the regional specific cerebral vascular comorbidities detected as white matter hyperintensity and reduction of cerebral blood flow. More specifically, unilateral vertebral artery stenosis led to asymmetric periventricular WMHs, while bilateral vertebral artery with lower blood flow led to symmetric periventricular WMHs. The comprehensive MRI protocol with functional and high resolution structural imaging sequences is capable of providing valuable information on blood flow supply in the vertebral artery and cerebrovascular ischemia in individuals having vertebral and cardiovascular abnormalities.

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