MTHFR C677T Polymorphism and Risk of Ischemic Stroke in Kashmiri Population
- *Corresponding Author:
- Syed Sameer Aga
Department of Basic Medical Sciences
College of Medicine, King Saud Bin Abdulaziz
University for Health Sciences
King Abdulaziz Medical City
National Guard Health Affairs
P.O. Box: 9515, Jeddah
Kingdom of Saudi Arabia
E-mail: [email protected]; [email protected] ksau-hs.edu.sa
Received Date: July 04, 2015; Accepted Date: August 22, 2015; Published Date: August 25, 2015
Citation: Nissar S, Rasool R, Bashir A, Aga SS (2015) MTHFR C677T Polymorphism and Risk of Ischemic Stroke in Kashmiri Population. Hereditary Genet 4:155. doi:10.4172/2161-1041.1000155
Copyright: © 2015 Nissar S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism as it is involved in DNA synthesis, DNA repair and DNA methylation. One of the common functional polymorphisms of MTHFR is 677 C→T which has been shown to impact various diseases, including stroke. To investigate the MTHFR C677T genotype frequency in stroke cases in the Kashmiri population, we designed a case- control study, where 70 stroke cases were studied for MTHFR C677T polymorphism against 160 controls taken from the general population employing the PCRRFLP technique. We found the frequency of the three different genotypes of MTHFR C677T in stroke case of Kashmiri population, i.e. CC, CT and TT, to be 71.4%, 17.1% and 11.4%, as compared to healthy controls, where they were 75.6%, 16.9% and 7.5%, respectively. There was no significant association between the MTHFR TT genotype and stroke. We conclude that the MTHFR C677T polymorphism is not involved in increasing the risk of stroke development in Kashmiri population.