alexa Mucin Expression and Corticosteroid Efficacy in Chronic Rhinosinusitis with Nasal Polyps | OMICS International | Abstract
ISSN: 2157-7536

Journal of Steroids & Hormonal Science
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Review Article

Mucin Expression and Corticosteroid Efficacy in Chronic Rhinosinusitis with Nasal Polyps

Peiró T1,2,5#, Milara J2,3,4,5#*, Armengot M6,7 and Cortijo J1,2,3,5

1Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain

2Research Foundation of General Hospital of Valencia, Spain

3Clinical research unit (UIC), University General Hospital Consortium, Valencia, Spain

4Department of Biotechnology, Universidad Politécnica de Valencia, Spain

5CIBERES, Health Institute Carlos III, Valencia, Spain

6Rhinology Unit, University General Hospital Consortium, Valencia, Spain

7Department of Medicine, Faculty of Medicine, University of Valencia, Spain

#authors Contributed equally

*Corresponding Author:
Javier Milara
Unidad de Investigación
Consorcio Hospital General Universitario
Avenida Tres Cruces s/n, E-46014 Valencia, Spain
Tel: +34 620231549
Fax: +34961972145
E-mail: [email protected]

Received date: December 31, 2013; Accepted date: January 20, 2014; Published date: February 01, 2014

Citation: Peiró T, Milara J, Armengot M, Cortijo J (2014) Mucin Expression and Corticosteroid Efficacy in Chronic Rhinosinusitis with Nasal Polyps. J Steroids Hormon Sci S12:007. doi:10.4172/2157-7536.S12-007

Copyright: © 2014 Peiró T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 Chronic rhinosinusitis with nasal polyps (CRSwNP) is an upper airway respiratory disease of the sinuses which may develop resistance to corticosteroid efficacy. Corticosteroids are the main therapy of this disease and as part of their anti-inflammatory activity they are known to exert an effect in mucin expression. This review aims to describe the current state-of-the-art knowledge regarding mucin expression in CRSwNP and its possible relation with corticosteroid efficacy, by highlighting the differential expression of membranetethered versus secreted mucins in different subsets of CRSwNP with an emphasis in corticosteroid non-responder patients. In addition, this review aims to suggest potential interactions between mucins and corticosteroids that could be addressed in future research to ascertain the role of mucins in the corticosteroid resistant mechanisms of this disease. In this sense, among the different mucins, we will highlight the membrane-tethered MUC1 and its potential role in corticosteroid-resistant CRSwNP, as it is currently considered an especially relevant mucin due to its anti-inflammatory properties.

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