Mucin Expression and Corticosteroid Efficacy in Chronic Rhinosinusitis with Nasal PolypsPeiró T1,2,5#, Milara J2,3,4,5#*, Armengot M6,7 and Cortijo J1,2,3,5
- *Corresponding Author:
- Javier Milara
Unidad de Investigación
Consorcio Hospital General Universitario
Avenida Tres Cruces s/n, E-46014 Valencia, Spain
Tel: +34 620231549
E-mail: [email protected]
Received date: December 31, 2013; Accepted date: January 20, 2014; Published date: February 01, 2014
Citation: Peiró T, Milara J, Armengot M, Cortijo J (2014) Mucin Expression and Corticosteroid Efficacy in Chronic Rhinosinusitis with Nasal Polyps. J Steroids Hormon Sci S12:007. doi:10.4172/2157-7536.S12-007
Copyright: © 2014 Peiró T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an upper airway respiratory disease of the sinuses which may develop resistance to corticosteroid efficacy. Corticosteroids are the main therapy of this disease and as part of their anti-inflammatory activity they are known to exert an effect in mucin expression. This review aims to describe the current state-of-the-art knowledge regarding mucin expression in CRSwNP and its possible relation with corticosteroid efficacy, by highlighting the differential expression of membranetethered versus secreted mucins in different subsets of CRSwNP with an emphasis in corticosteroid non-responder patients. In addition, this review aims to suggest potential interactions between mucins and corticosteroids that could be addressed in future research to ascertain the role of mucins in the corticosteroid resistant mechanisms of this disease. In this sense, among the different mucins, we will highlight the membrane-tethered MUC1 and its potential role in corticosteroid-resistant CRSwNP, as it is currently considered an especially relevant mucin due to its anti-inflammatory properties.