Mucin Family Genes are Downregulated in Colorectal Cancer Patients
Mohammad Azhar Aziz*, Majed AlOtaibi, Abdulkareem AlAbdulrahman, Mohammed AlDrees and Ibrahim AlAbdulkarim
Department of Medical Genomics, KIng Abdullah Intl. Med. Res. Ctr., King Saud Bin Abdul Aziz University for Health Sciences, Riyadh, Saudi Arabia
- *Corresponding Author:
- Mohammad Azhar Aziz
PO Box 22490, Mail Code 2216
King Abdul Aziz Medical City
Riyadh, 11426, Saudi Arabia
Tel: +966 18016030
Fax: +966 18011111 ext 16662
E-mail: [email protected]
Received date: May 26, 2014; Accepted date: September 21, 2014; Published date: September 27, 2014
Citation: Aziz MA, AlOtaibi M, AlAbdulrahman A, AlDrees M, AlAbdulkarim I (2014) Mucin Family Genes are Downregulated in Colorectal Cancer Patients. J Carcinogene Mutagene S10:009. doi: 10.4172/2157-2518.S10-009
Copyright: © 2014 Aziz MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mucins are very well known to be associated with different types of cancer. Their role in colorectal cancer has been extensively studied without direct correlation with their change in expression levels. In the present study we employed the human exon array from Affymetrix to provide evidence that mucin family genes are downregulated in colorectal cancer tumor samples. We analyzed 92 samples taken from normal and tumor tissues. All mucin family genes except MUCL1 were downregulated with the fold change value ranging from -3.53 to 1.78 as calculated using AltAnalyze software. Maximum drop in RNA transcripts were observed for MUC2 with a fold change of -3.53. Further, we carried out Integromics analysis to analyze mucin genes using hierarchical clustering. MUC1 and MUC4 were found to be potential biomarkers for human colorectal cancer. Top upstream regulators were identified for mucin genes. Network analyses were carried out to further our understanding about potential mechanisms by which mucins can be involved in causing colorectal cancer.