alexa Multicentric Reticulohistiocytosis: A Reason for Erosive Arthritis
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Case Report

Multicentric Reticulohistiocytosis: A Reason for Erosive Arthritis

Yuan Yao1, Jinjun Wang2, Bin Liu1,2*, Xuan Zhang3 and Stanley M Naguwa2

1 Department of Rheumatology and Immunology, The Affiliated Hospital of Medical College Qingdao University, No.16 Jiang Su Lu, Shi Nan District, Qingdao City, Shandong Province, 266003, China

2 Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA

3 Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China

*Corresponding Author:
Bin Liu
Department of Rheumatology and Immunology
The Affiliated Hospital of Medical College Qingdao University
No. 16 Jiang Su Lu, Shi Nan District
Qingdao City, Shandong Province, 266003, China
Tel: 5307509827
E-mail : [email protected]

Received date: June 03, 2014; Accepted date: June 27, 2014; Published date: July 04, 2014

Citation: Yao Y, Wang J, Liu B, Zhang X, Naguwa SM (2014) Multicentric Reticulohistiocytosis: A Reason for Erosive Arthritis. J Diabetes Metab 5:400. doi:10.4172/2155-6156.1000400

Copyright: © 2014 Yao Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.




Multicentric Reticulohistiocytosis (MRH) is a rare histiocytic disorder that primarily involves the skin and joints but can affect multiple visceral organs. A female patient presented a characteristic papulonodular skin eruption and polyarthritis with positive Antinuclear Antibody (ANA), and skin biopsy findings demonstrated classic features of MRH. The patient’s clinical manifestations were in remission after treatment, yet X-ray showed progressive erosions of finger joints. MRH is an aggressive, debilitating and disabling condition, an optimal treatment strategy is necessary performed to improve outcome.


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