Multifaced pknE: Apoptosis Inhibition, HIV Co-Infection, Host Signaling Cross-Talk and in Orchestrating the Physiology of Mycobacterium tuberculosis
- Corresponding Author:
- Sujatha Narayanan
Department of Immunology
National Institute for Research in Tuberculosis Research
Tel: +91- 44-28369627
E-mail: [email protected]
Received Date: May 25, 2016; Accepted Date: June 07, 2016; Published Date: June 14, 2016
Citation: Parandhaman DK, Hassan S, Narayanan S (2016) Multifaced pknE: Apoptosis Inhibition, HIV Co-Infection, Host Signaling Cross-Talk and in Orchestrating the Physiology of Mycobacterium tuberculosis. J Microb Biochem Technol 8:231-235. doi: 10.4172/1948-5948.1000291
Copyright: © 2016 Parandhaman DK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Serine/threonine protein kinases (STPK) regulate various functions in the pathogenesis of Mycobacterium tuberculosis and are listed as prime targets for the cure of tuberculosis (TB) disease. Genetic deletion of pknE helped to unravel its role in nitric oxide stress, an important antimicrobial agent produced by host cells. pknE is well characterized for its functions in host as well as in M. tuberculosis physiology. The current review summarizes the multiple roles of pknE in human pathogenesis. pknE remains the only STPK that has the standalone function of apoptosis suppression and probable role in HIV co-infection.