alexa Multiglandular Autoimmune Diseases of the Thyroid, Salivary Gland, and Liver along with Atrophic Gastritis: A Case Report | OMICS International | Abstract
ISSN: 2167-7948

Journal of Thyroid Disorders & Therapy
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Case Report

Multiglandular Autoimmune Diseases of the Thyroid, Salivary Gland, and Liver along with Atrophic Gastritis: A Case Report

Soo Jin Lee1, June-Key Chung1,2,4,5*, Taemoon Chung2, Hyewon Youn1,4,5, Jin Chul Paeng1, Gi Jeong Cheon1,4, Keon Wook Kang1,2,4 and Dong Soo Lee1,3
1Department of Nuclear Medicine, Seoul National University Hospital, Korea
2Department of Biomedical Sciences, Seoul National University, Korea
3Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Korea
4Cancer Research Institute, Seoul National University, Korea
5Tumor Microenvironment Global Core Research Center, Seoul National University, Korea
Corresponding Author : June-Key Chung
Department of Nuclear Medicine
Seoul National University Hospital Seoul
National University College of Medicine Seoul, Korea
Tel: 82-2-2072-3376
Fax: 82-2-745-7690
E-mail: [email protected]
Received August 12, 2014; Accepted October 09, 2014; Published Octobger 11, 2014
Citation: Soo Jin L, June-K C, Taemoon C, Hyewon Y, Jin C P, et al. (2014) Multiglandular Autoimmune Diseases of the Thyroid, Salivary Gland, and Liver along with Atrophic Gastritis: A Case Report. Thyroid Disorders Ther 3:164. doi:10.4172/2167-7948.1000164
Copyright: © 2014 Soo Jin L et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Multiple mechanisms have been suggested for the pathogenesis of these multiglandular autoimmune diseases. One of proposed mechanisms in the multiglandular autoimmune disease is initiated by antibodies. However, the results are not definitive and remain controversial. We investigated a woman with multiple autoimmune diseases, in whose serum the mRNA of sodium iodide symporter (NIS) was found by nested reverse transcription polymerase chain reaction (RT-PCR). In this patient, multiple autoimmune diseases were initially developed as thyroiditis, followed by Sjögren syndrome, hepatitis, and finally a diagnosis of atrophic gastritis. NIS is known to be expressed on organs affected by these diseases. The mRNA of NIS was found in the serum of this patient by nested RT-PCR. The pathogenesis of multiglandular autoimmune disease is still not clear. We suggest that anti NIS antibodies can serve as a marker to monitor the pathogenesis of multiglandular autoimmune disease.

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