alexa Multiple Cerebral Infarctions as an Initial Manifestation of Systemic Lupus Erythematosus with Concomitant Hypereosinophilic Syndrome | OMICS International| Abstract

Lupus: Open Access

  • Case Report   
  • Lupus Open Access 2016, Vol 1(1): 109

Multiple Cerebral Infarctions as an Initial Manifestation of Systemic Lupus Erythematosus with Concomitant Hypereosinophilic Syndrome

Akihiro Nakamura1,2*, Tomoya Miyamura1, Brian Wu2 and Eiichi Suematsu1
1Department of Internal Medicine and Rheumatology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan
2Department of Genetics and Development, Krembil Research Institute, University of Toronto, University Health Network, Toronto, Ontario, Canada
*Corresponding Author : Akihiro Nakamura, Department of Internal Medicine and Rheumatology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan, Tel: +1-416-603-5800, Email: [email protected]

Received Date: Jan 04, 2016 / Accepted Date: Jan 25, 2016 / Published Date: Feb 17, 2016

Abstract

A 51-year old woman with drowsy consciousness and weakness in bilateral upper and lower extremities was admitted to our hospital. Laboratory test on admission showed eosinophilia, proteinuria, hypoalbuminemia, and elevated creatine kinase-MB. She also had positive antinuclear antibody, anti-ribonucleoprotein antibody and anti- Smith antibody as well as decreased levels of complements. Brain MRI showed multiple cerebral infarcts in both hemispheres. Renal biopsy determined class IV lupus nephritis. Vasculopathy and hypercoagulopathy induced by systemic lupus erythematosus rarely concomitant with hypereosinophilic syndrome were considered as main causes of multiple cerebral infarctions in this patient. The symptoms and laboratory data were gradually recovered with an intravenous methylprednisolone pulse therapy followed by oral prednisolone and monthly intravenous cyclophosphamide therapies.

Keywords: Hypereosinophilic syndrome; Systemic lupus erythematosus; Cerebral infarction; Lupus nephritis; Prednisolone; Cyclophosphamide

Citation: Nakamura A, Miyamura T, Wu B, Suematsu E (2016) Multiple Cerebral Infarctions as an Initial Manifestation of Systemic Lupus Erythematosus with Concomitant Hypereosinophilic Syndrome. Lupus Open Access 1: 109.

Copyright: © 2016 Nakamura A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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