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Multiple Effects of Molecular Hydrogen and its Distinct Mechanism | OMICS International | Abstract
ISSN: 2329-6895

Journal of Neurological Disorders
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Review Article

Multiple Effects of Molecular Hydrogen and its Distinct Mechanism

Mami Noda1*, Kyota Fujita1, Ikuroh Ohsawa2, Masafumi Ito3 and Kinji Ohno4
1Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2Research Team for Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo173-0015, Japan
3Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo173-0015, Japan
4Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Corresponding Author : Mami Noda
Lab. Pathophysiology
Graduate School of Pharmaceutical Sciences
Kyushu University, Fukuoka 812-8582, Japan
Tel: 81-92-642-6574
E-mail: [email protected]
Received August 26, 2014; Accepted October 27, 2014; Published October 29, 2014
Citation: Noda M, Fujita K, Ohsawa I, Ito M, Ohno K (2014) Multiple Effects of Molecular Hydrogen and its Distinct Mechanism. J Neurol Disord 2:189. doi: 10.4172/2329-6895.1000189
Copyright: © 2014 Noda M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Molecular hydrogen (H2) has been reported to be effective for a variety of disorders and its effect has been ascribed to a selective scavenge of hydroxyl radicals (•OH) at the beginning. Consumption of H2 was either by inhalation, drinking H2-containing water (H2 water), or infusion of H2-containing saline. Among various disorders, animal model of ischemic injury and Parkinson’s disease showed significant amelioration after H2 treatment. The mechanism of neuroprotection, however, is not simple. Multiple mechanisms may exist to produce acute and chronic effect. For chronic effect, H2-induced neuroprotection takes several days to develop and lasted several days, suggesting that H2 may work as a modulator of signal transduction as indicated by allergy model. The evidence that drinking H2 water was the most effective way rather than inhaling H2 in Parkinson’s disease model animal led not lead to the finding that H2 induces ghrelin production and release from the stomach by activating β1 adrenergic receptors. The distinct mechanism due to the brain-stomach connection may help to understand the broad spectrum of H2 function. In addition, clinical trials have shown promising results.


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