Multiple Pulmonary and Splenic Infarcts Triggered by Acute CMV Infection and Transient Double Antiphospholipid Antibody Positivity in a Patient Carrier for JAK-2 MutationEnrique EV1, Álvarez BM1, Farré BA2 and Reig JA3*
- *Corresponding Author:
- Reig JA
Senior consultant, Systemic Autoimmune Diseases Service
Department of Medicine, Vall d’Hebrón University Hospital
Professor of Medicine, Universitat Autònoma
Tel: +34 93 489 41 94
E- mail: [email protected]/[email protected]
Received date: January 20, 2015; Accepted date: January 25, 2015; Published date: February 17, 2016
Citation: Enrique EV, Álvarez BM, Farré BA, Reig JA (2016) Multiple Pulmonary and Splenic Infarcts Triggered by Acute CMV Infection and Transient Double Antiphospholipid Antibody Positivity in a Patient Carrier for JAK-2 Mutation. Lupus Open Access 1:101.
Copyright: © 2016 Enrique EV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The co-existence of inherited thrombophilia with antiphospholipid antibody (aPL) positivity is not uncommon. This association does not overrule the diagnosis of antiphospholipid syndrome. Infection may present together with transient aPL positivity, usually aCL-IgM isotype. Thus certain infections, virus particularly, may increase “per se” thrombotic risk. Herein, we communicate the case of a 29-year-old man who sought medical attention because of a ten days course left-side abdominal pain, cough, fever, fatigue, arthralgia and mild dyspnoea. The patient was diagnosed of multiple pulmonary and splenic infarcts. Interestingly, laboratory results showed the presence of JAK2- V617F mutation, positive CMV serology, first IgM and IgG further, as well as LA test and aCL-IgM transiently but recurrently positive. The role played by these aPL transiently positive antibodies – laboratory category I – as a trigger in the development of this thrombotic diathesis is being discussed.