alexa Multi-target Therapy for Subcellular Incompatibility in Brain Disorders
ISSN: 2168-975X

Brain Disorders & Therapy
Open Access

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Review Article

Multi-target Therapy for Subcellular Incompatibility in Brain Disorders

Jin-Hui Wang1,2,3* and Shan Cui1
1State Key Lab for Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
2University of Chinese Academy of Sciences, Beijing, China
3Qingdao University, Medical College, 38 Dengzhou, Shandong, China
Corresponding Author : Jin-Hui Wang
State Key Lab for Brain and Cognitive Sciences
Institute of Biophysics, Chinese Academy of Sciences
15 Datun Road, Beijing China 100101
Tel: +861064888472
E-mail: [email protected]
Received: November 20, 2015 Accepted: December 21, 2015 Published: December 28, 2015
Citation: Wang JH, Cui S (2015) Multi-target Therapy for Subcellular Incompatibility in Brain Disorders. Brain Disord Ther 4:200. doi:10.4172/2168-975X.1000200
Copyright: © 2015 Wang JH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Most brain disorders are caused by a number of pathogenic factors, which lead to the pathological impairment in subcellular organelles and compartments. Recent studies indicate that pathological changes in certain brain disorders include the incoordination among different nerve cells and the incompatibility among subcellular compartments. In this regard, therapeutic strategies for these brain disorders are better to act on multiple molecular and cellular targets in order to correct the neuron-specific incoordination and the subcellular incompatibility. The strategy of multi-target therapy is expected to be advanced to that of single-target therapy that leads to long-term drug-resistance or drugdependence. In this mini-review, we summarize the data about subcellular incompatibility in certain brain disorders (such as epilepsy, anxiety and depression) and propose the therapeutic principle of multiple targets for their treatments.

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