Municipal Auto-Battery Recycling-Site Leachate Activates Key Enzymes Linked to Non-Insulin Dependent Diabetes Mellitus (NIDDM) and Hypertension
Akintunde JK* and Oboh G
Functional Foods, Nutraceuticals and Phytomedicine Research Laboratory, Department of Biochemistry, Federal University of Technology, P.M.B., 704, Akure 340001, Nigeria
- *Corresponding Author:
- Akintunde JK
Nutraceuticals and Phytomedicine Research Laboratory
Department of Biochemistry
Federal University of Technology, P.M.B., 704, Akure 340001, Nigeria
E-mail: [email protected]
Received date: September 29, 2012; Accepted date: November 28, 2012; Published date: December 04, 2012
Citation: Akintunde JK, Oboh G (2013) Municipal Auto-Battery Recycling-Site Leachate Activates Key Enzymes Linked to Non-Insulin Dependent Diabetes Mellitus (NIDDM) and Hypertension. J Diabetes Metab 4:235. doi: 10.4172/2155-6156.1000235
Copyright: © 2013 Akintunde JK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The rate at which diabetes mellitus and hypertension affect people in the whole world is tremendously increasing due to continuous occupational exposure to complex mixtures of the environment. Therefore, in this study the interaction treatment of municipal auto-battery leachate (MABL) and Elewi-Odo municipal auto-battery recycling-site leachate (EOMABRL), a popular agent for the activation of diabetes and hypertension with key enzymes linked to NIDDM (α-glucosidase and α-amylase and hypertension (Angiotensin 1-converting enzyme (ACE) were evaluated. Both types of leachates significantly (p<0.05) activated α-glucosidase, α-amylase and ACE activities in a dosedependent manner; however, the MABL were stronger activators of α-amylase and α-glucosidase than EOMABRL. Similarly, the MABL strongly activated Agiotensin 1-converting enzyme (Pro-hypertensive agent) than EOMABRL and significantly (p<0.05) increased malondiadehyde (MDA) production in the pancreas in dose-dependent manner. Therefore, increased activity of α-glucosidase, α-amylase, ACE and induction of lipid peroxidation in battery leachate treated-rat is the mechanism of toxicity through which they induce NIDDM and hypertension.