alexa Municipal Auto-Battery Recycling-Site Leachate Activates Key Enzymes Linked to Non-Insulin Dependent Diabetes Mellitus (NIDDM) and Hypertension
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Municipal Auto-Battery Recycling-Site Leachate Activates Key Enzymes Linked to Non-Insulin Dependent Diabetes Mellitus (NIDDM) and Hypertension

Akintunde JK* and Oboh G

Functional Foods, Nutraceuticals and Phytomedicine Research Laboratory, Department of Biochemistry, Federal University of Technology, P.M.B., 704, Akure 340001, Nigeria

*Corresponding Author:
Akintunde JK
Functional Foods
Nutraceuticals and Phytomedicine Research Laboratory
Department of Biochemistry
Federal University of Technology, P.M.B., 704, Akure 340001, Nigeria
Fax: +23408064156056
E-mail: [email protected]

Received date: September 29, 2012; Accepted date: November 28, 2012; Published date: December 04, 2012

Citation: Akintunde JK, Oboh G (2013) Municipal Auto-Battery Recycling-Site Leachate Activates Key Enzymes Linked to Non-Insulin Dependent Diabetes Mellitus (NIDDM) and Hypertension. J Diabetes Metab 4:235. doi: 10.4172/2155-6156.1000235

Copyright: © 2013 Akintunde JK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The rate at which diabetes mellitus and hypertension affect people in the whole world is tremendously increasing due to continuous occupational exposure to complex mixtures of the environment. Therefore, in this study the interaction treatment of municipal auto-battery leachate (MABL) and Elewi-Odo municipal auto-battery recycling-site leachate (EOMABRL), a popular agent for the activation of diabetes and hypertension with key enzymes linked to NIDDM (α-glucosidase and α-amylase and hypertension (Angiotensin 1-converting enzyme (ACE) were evaluated. Both types of leachates significantly (p<0.05) activated α-glucosidase, α-amylase and ACE activities in a dosedependent manner; however, the MABL were stronger activators of α-amylase and α-glucosidase than EOMABRL. Similarly, the MABL strongly activated Agiotensin 1-converting enzyme (Pro-hypertensive agent) than EOMABRL and significantly (p<0.05) increased malondiadehyde (MDA) production in the pancreas in dose-dependent manner. Therefore, increased activity of α-glucosidase, α-amylase, ACE and induction of lipid peroxidation in battery leachate treated-rat is the mechanism of toxicity through which they induce NIDDM and hypertension.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords