alexa Muscle Mitochondrial Dysfunction in Horses Affected by
ISSN: 2167-7662

Bioenergetics: Open Access
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Research Article

Muscle Mitochondrial Dysfunction in Horses Affected by Acute Laminitis

Didier Serteyn1,3*, Geoffroy de la Rebière de Pouyade1,2, Charlotte Sandersen1,2, Alexandra Salciccia1, Sigrid Grulke1, Ange Mouithys-Mickalad2, Thierry Franck2, Jean-Philippe Lejeune1,3 and Justine Ceusters2
1Department of Clinical Sciences, Equine Clinic, Faculty of Veterinary Medicine B41, University of Liege, 4000 Sart Tilman, Belgium
2Centre for Oxygen Research and Development, B6a, University of Liege, 4000 Sart Tilman, 4000, Belgium
3Equine Research Centre, Mont-le-Soie, 6690 Vielsalm, Belgium
Corresponding Author : Didier Serteyn
Department of Clinical Sciences
Equine Clinic, Faculty of Veterinary Medicine B41
University of Liege, 4000 Sart Tilman, Belgium
Tel: +32 4-366-41-03
E-mail: [email protected]
Received July 16, 2014; Accepted September 29, 2014, Published October 6, 2014
Citation: Serteyn D, Pouyade G R, Sandersen C, Salciccia A, Grulke S, et al (2014) Muscle Mitochondrial Dysfunction in Horses Affected by Acute Laminitis. Bioenergetics 3:120.doi:10.4172/2167-7662.1000120
Copyright: © 2014 Serteyn D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Laminitis is a common and debilitating disease affecting horses and ponies. It often leads to the demise of the animal. Energy deficiency is suspected to entrain the disruption of the hemidesmosomes leading to the failure of the dermal-epidermal interface. The aim of this study was to measure the muscle mitochondrial function by high resolution respirometry. Muscle micro-biopsies were obtained from 11 horses affected by acute metabolic laminitis, 6 horses affected by acute laminitis resulting from a systemic inflammation response syndrome and 28 healthy horses distributed in 2 control groups: 17 horses with a body condition score [BSC, ranging from 0 (emaciated) to 5 (obese)] of 2 to 3 and 11 horses with a BSC of 4 to 5. During the acute phase of laminitis, a significant reduction of the muscle mitochondrial respiration was observed. The muscle mitochondrial dysfunction occurred independently of the etiology (metabolic disorder or systemic inflammation) leading to laminitis. The reduction of the oxidative phosphorylation and of the maximal respiratory capacity (after uncoupling) may induce depletion of the cell’s ATP content. If the same mitochondrial alteration occurs in the foot lamina, mitochondria targeting should be considered for the future, not only to better understand the physiopathology of the disease but also to maintain and to support the mitochondrial function before reaching the « mitochondrial dysfunction threshold » that may lead to the failure of the dermal-epidermal interface.

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