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ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Mutated LXR-Α Gene within Blood Mononuclear Cells of CHD Patients: Significance of Serum Factors

Vivek P Dave1, Deepak Kaul1*, Yashpaul Sharma2 Rajasri Bhattacharya1 and Veena Dhawan1
1Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh – 160012, India
2Department of Cardiology, Post Graduate Institute of Medical Education and Research, Chandigarh – 160012, India
Corresponding Author : Deepak Kaul
Professor & Head, Department of Experimental Medicine and Biotechnology
Post Graduate Institute of Medical Education and Research
Chandigarh – 160012, India
Tel: 91-172-2755228
Fax: 91-0172-2744401
E-mail: [email protected]
Received December 15, 2010; Accepted February 21, 2011; Published February 23, 2011
Citation: Dave VP, Kaul D, Sharma Y, Bhattacharya R, Dhawan V (2011) Mutated LXR-A Gene within Blood Mononuclear Cells of CHD Patients: Significance of Serum Factors. J Clinic Experiment Cardiol 2:125. doi: 10.4172/2155-9880.1000125
Copyright: © 2011 Dave VP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Several lines of evidence attest to the fact that the Liver X Receptor (LXR) -α dependent cross talk between lipid metabolism and inflammation may be of crucial importance in atherogenesis. The present study unambiguously revealed that the serum derived from coronary heart disease (CHD) patients does not possess any factor that had the inherent capacity to induce the observed LXR-α gene mutation in such patients. Surprisingly our experiments clearly indicated that vitamin D 3 could restore in part the functional activity of mutated LXR-α gene found in peripheral blood mononuclear cells of CHD patients. Our data also indicated that CHD patients contain significant low level of vitamin D 3 in their serum and this level is increased in such patients who are treated with atorvastatin. Based upon our findings, it’s not unlikely that restoration of serum vitamin D 3 level in such patients may be useful in arresting the progression of coronary atherosclerosis.

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