alexa Mutated LXR-Α Gene within Blood Mononuclear Cell
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Mutated LXR-Α Gene within Blood Mononuclear Cells of CHD Patients: Significance of Serum Factors

Vivek P Dave1, Deepak Kaul1*, Yashpaul Sharma2 Rajasri Bhattacharya1 and Veena Dhawan1
1Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh – 160012, India
2Department of Cardiology, Post Graduate Institute of Medical Education and Research, Chandigarh – 160012, India
Corresponding Author : Deepak Kaul
Professor & Head, Department of Experimental Medicine and Biotechnology
Post Graduate Institute of Medical Education and Research
Chandigarh – 160012, India
Tel: 91-172-2755228
Fax: 91-0172-2744401
E-mail: [email protected]
Received December 15, 2010; Accepted February 21, 2011; Published February 23, 2011
Citation: Dave VP, Kaul D, Sharma Y, Bhattacharya R, Dhawan V (2011) Mutated LXR-A Gene within Blood Mononuclear Cells of CHD Patients: Significance of Serum Factors. J Clinic Experiment Cardiol 2:125. doi: 10.4172/2155-9880.1000125
Copyright: © 2011 Dave VP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google


Several lines of evidence attest to the fact that the Liver X Receptor (LXR) -α dependent cross talk between lipid metabolism and inflammation may be of crucial importance in atherogenesis. The present study unambiguously revealed that the serum derived from coronary heart disease (CHD) patients does not possess any factor that had the inherent capacity to induce the observed LXR-α gene mutation in such patients. Surprisingly our experiments clearly indicated that vitamin D 3 could restore in part the functional activity of mutated LXR-α gene found in peripheral blood mononuclear cells of CHD patients. Our data also indicated that CHD patients contain significant low level of vitamin D 3 in their serum and this level is increased in such patients who are treated with atorvastatin. Based upon our findings, it’s not unlikely that restoration of serum vitamin D 3 level in such patients may be useful in arresting the progression of coronary atherosclerosis.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version