alexa Mycobacterium Tuberculosis Heat Shock Protein 16 as a P
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Mycobacterium Tuberculosis Heat Shock Protein 16 as a Potential Marker for Latent TB: A Preliminary Findings

Rajpal SK1, Snehal SW1, Milind SP1, Hemant JP2, Girdhar MT1 and Hatim FD1*
1Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur - 440 010, India
2Environmental Genomics Unit, National Environmental Engineering Research Institute, Nehru Marg, Nagpur-440020, India
Corresponding Author : Hatim F Daginawala
Biochemistry Research Laboratory
Central India Institute of Medical Sciences
Nagpur- 440 010, India
Tel: (0712)2236441; 2233381
Fax: (0712)2236416
E-mail: [email protected]
Received: March 29, 2011; Accepted: October 05, 2011; Published: October 07, 2011
Citation: Rajpal SK, Snehal SW, Milind SP, Hemant JP, Girdhar MT, et al. (2011) Mycobacterium Tuberculosis Heat Shock Protein 16 as a Potential Marker for Latent TB: A Preliminary Findings. J Clin Cell Immunol 2:115. doi:10.4172/2155-9899.1000115
Copyright: © 2011 Rajpal SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Identifying latent Tuberculosis (TB) is a key component of global efforts to eliminate TB. Heat shock proteins (Hsps) of mycobacteria are up regulated in response to various environmental stresses during infection. The present study was undertaken to evaluate the diagnostic efficacy of Mycobacterium Tuberculosis (MTB) Hsp16, MTB Hsp65 and MTB Hsp71 in latent and active TB in a high TB prevalence area by ELISA method. The mean optical density for Hsp16 as compared to Hsp65 and Hsp71 in latent TB subjects was significantly higher than the active subjects with significant P value of 0.0004. A preliminary finding indicates that the Hsp16 is more specific to latency and may be useful as a diagnostic marker for latent TB infection.

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