alexa Mycological Findings of Sputum Samples from Pulmonary Tuberculosis Patients Attending TB Clinic in Nairobi, Kenya
ISSN: 2161-0517

Virology & Mycology
Open Access

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Research Article

Mycological Findings of Sputum Samples from Pulmonary Tuberculosis Patients Attending TB Clinic in Nairobi, Kenya

Elizabeth Nyambura Mwaura1, Vivian Matiru1 and Christine Bii 2*

1Jomo Kenyatta University of Agriculture and Technology (JKUAT), Nairobi, Kenya

2Mycology Laboratory, Centre for Microbiology Research (CMR), Kenya Medical Research Institute (KEMRI), Nairobi, Kenya

*Corresponding Author:
Christine Bii
Mycology Laboratory
Centre for Microbiology Research (CMR)
Kenya Medical Research Institute
P.O Box 2632-00202, Nairobi, Kenya
E-mail: [email protected], [email protected]

Received date: July 31, 2013; Accepted date: August 31, 2013; Published date: September 03, 2013

Citation: Mwaura EN, Matiru V, Bii C (2013) Mycological Findings of Sputum Samples from Pulmonary Tuberculosis Patients Attending TB Clinic in Nairobi, Kenya. Virol Mycol 2:119. doi: 10.4172/2161-0517.1000119

Copyright: © 2013 Mwaura EN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: To determine the prevalence of fungal pathogens in patients with pulmonary tuberculosis at Mbagathi District Hospital TB clinic. Design: One hundred and seventy two sputum samples were collected from patients who were confirmed to have pulmonary tuberculosis at Mbagathi District Hospital TB clinic. These samples were subjected to mycological investigation using microscopy and culture. Results: Pulmonary fungal pathogens were isolated as co-pathogens with Mycobacterium tuberculosis in 76 (44.18%). Yeasts accounted for 46/172 (26.7%), with 33/172 (19%) being Candida albicans, 3/172 (1.7%) were identified as Candida dubliniensis, 1/172 (0.6%) was Candida guilliermondii, while 3/172(1.7%) were Candida tropicalis. Cryptococcus laurentii was isolated in 2/172 (1.2%). Colonization of Mycobacterium tuberculosis with moulds was as follows: 2/172 (1.2%) Aspergillus flavus, 3/172 (1.7%) Aspergillus fumigatus 4/172 (2.3%) Aspergillus niger, 2/172 (1.2%) Scytalidium hyalinum and 4/172 (2.3%) Trichosporon asahii. Pneumocystis jirovencii oocysts were positive in 19/172 (11.0%) on Toluidine O blue. Gram stain of the sputum samples yielded: 4/172 (2.3%) Gram negative rods, 10/172 (5.8%) Gram positive cocci and 6/172(3.5%) Gram positive rods. Conclusion: Pathogenic fungi and other bacterial pathogens may be significant co-infecting pathogens complicating the management of TB. Clinicians in Kenya should be aware of co-infection of Mycobacterium tuberculosis with opportunistic pulmonary fungal and bacterial pathogens. HIV infection is a significant pre-disposition to pulmonary tuberculosis. The two conditions present severe immunosuppression. Confounded by prolonged TB treatment, this group represents a high risk for acquiring opportunistic fungal pathogens.

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